倍频 Nd:YAG 激光在角膜新生血管治疗中的作用

Role of Frequency Doubled Nd: Yag Laser in Treatment of Corneal Neovascularisation.

作者信息

Kumar Jitendra, Gehra Aakanksha, Sirohi Naveen

机构信息

Assistant Professor and Head of Department, Department of Ophthalmology, M.L.B Medical College , Jhansi, India .

Junior Resident, Department of Ophthalmology, M.L.B Medical College , Jhansi, India .

出版信息

J Clin Diagn Res. 2016 Apr;10(4):NC01-4. doi: 10.7860/JCDR/2016/17502.7543. Epub 2016 Apr 1.

DOI:10.7860/JCDR/2016/17502.7543

PMID:27190847

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4866145/

Abstract

INTRODUCTION

Cornea is the outermost transparent coat of eye along with sclera, for which its avascularity is essential for maintaining its transparency to have normal visual acuity. Corneal neovascularization is characterized by the invasion of new blood vessels into the cornea from the limbus interfering with corneal transparency, resulting in reduction in visual acuity. It also increases the risk of graft rejection. So their being a dire need to treat corneal neovascularisation, with laser photocoagulation being an effective means of treating it.

AIM

To evaluate the efficacy and safety of frequency doubled Nd:Yag laser photocoagulation in treatment of corneal neovascularisation.

MATERIALS AND METHODS

A single centre prospective study was carried out on patients attending the outpatient department of ophthalmology in Maharani Laxmi Bai Medical College, Jhansi. Forty eyes of 40 patients having corneal neovascularisation with quiescent eyes satisfying the inclusion criteria were selected and treated with laser. The efficacy of the procedure was noted in terms of area of corneal neovascularisation, status of treated vessels, area of corneal opacity, visual acuity. The above parameters of selected patients were recorded before treatment and subsequent follow up visits at 1 week, 1 month, 2 month and 3 month after laser. Paired t-test was used to calculate the p-value.

RESULTS

There was a statistically significant difference in the percentage mean area of corneal neovascularisation with a pre laser value of 31.93% to 17.62% after 3 months of laser treatment (p-value<0.0001). The percentage mean area of corneal opacity decreased from 30.75% to 23.74% (p<0.0001). Out of 185 corneal vessels, 99 (53.51%) vessels were completely occluded,17(9.18%) vessels were partially occluded and 69(37.29%) vessels were recanalised at the end of 3 months after laser treatment.

CONCLUSION

Frequency doubled Nd:Yag laser is an effective and safe method for the treatment of corneal neovascularisation.

摘要

引言

角膜是眼睛最外层的透明组织，与巩膜相连，其无血管状态对于维持透明度以获得正常视力至关重要。角膜新生血管形成的特征是新血管从角膜缘侵入角膜，干扰角膜透明度，导致视力下降。它还增加了移植排斥的风险。因此迫切需要治疗角膜新生血管，激光光凝是治疗它的一种有效手段。

目的

评估倍频Nd:YAG激光光凝治疗角膜新生血管的有效性和安全性。

材料与方法

在占西玛哈拉尼·拉克希米·拜伊医学院眼科门诊对患者进行单中心前瞻性研究。选择40例有角膜新生血管且符合纳入标准的静止眼患者的40只眼，用激光进行治疗。根据角膜新生血管面积、治疗血管状态、角膜混浊面积、视力评估该手术的疗效。在激光治疗前及治疗后1周、1个月、2个月和3个月的后续随访中记录所选患者的上述参数。采用配对t检验计算p值。

结果

激光治疗3个月后，角膜新生血管平均面积百分比有统计学显著差异，激光治疗前为31.93%，治疗后为17.62%（p值<0.0001）。角膜混浊平均面积百分比从30.75%降至23.74%（p<0.0001）。在185条角膜血管中，激光治疗3个月后，99条（53.51%）血管完全闭塞，17条（9.18%）血管部分闭塞，69条（37.29%）血管再通。