Bilgic Özlem, Altınyazar Hilmi Cevdet, Eryılmaz Dilek, Tuğrul Zehra Ayça
Selcuk University, Konya, Turkey.
An Bras Dermatol. 2016 Apr;91(2):156-9. doi: 10.1590/abd1806-4841.20164622.
Although the pathogenesis of androgenetic alopecia is not completely understood, the roles of genetic susceptibility and androgens are well-known. A lower ratio of the second digit (index finger = 2D) to the fourth digit (ring finger = 4D) length has been hypothesized to reflect prenatal androgen exposure and/or higher sensitivity to androgens.
To determine the relationship between the second to fourth digit length ratio and androgenetic alopecia.
Finger length measurements were made by a digital vernier calliper. Androgenetic alopecia severity was assessed using the Hamilton-Norwood scale. Subjects with an androgenetic alopecia score of grade III or more were included in the study.
A total of 189 males with androgenetic alopecia and 171 healthy controls were enrolled in the study. The age range of participants was 19-65 years. The 2D:4D ratios in patients with androgenetic alopecia were significantly lower than those of healthy controls for the right hand; however, no significant difference was found for the left hand. Average 2D:4D ratios in androgenetic alopecia patients were also lower than in controls. No significant relationship was observed between androgenetic alopecia severity and 2D:4D ratios.
Our data support the anatomical evidence of in utero androgen exposure and/or an individual's sensitivity to androgens in patients with androgenetic alopecia. Furthermore, the right hand 2D:4D ratio might be an indicator of androgenetic alopecia development.
尽管雄激素性脱发的发病机制尚未完全明确，但遗传易感性和雄激素的作用已为人熟知。有假说认为，食指（第二指 = 2D）与无名指（第四指 = 4D）长度之比降低反映了产前雄激素暴露和/或对雄激素的更高敏感性。
确定第二至第四指长度比与雄激素性脱发之间的关系。
使用数字游标卡尺测量手指长度。采用汉密尔顿 - 诺伍德量表评估雄激素性脱发的严重程度。研究纳入雄激素性脱发评分为III级或更高的受试者。
共有189名雄激素性脱发男性和171名健康对照者参与研究。参与者的年龄范围为19至65岁。雄激素性脱发患者右手的2D:4D比值显著低于健康对照者；然而，左手未发现显著差异。雄激素性脱发患者的平均2D:4D比值也低于对照组。未观察到雄激素性脱发严重程度与2D:4D比值之间存在显著关系。
我们的数据支持了雄激素性脱发患者子宫内雄激素暴露和/或个体对雄激素敏感性的解剖学证据。此外，右手2D:4D比值可能是雄激素性脱发发展的一个指标。
