Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Harvard Skin Disease Research Center, Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Immunity. 2016 May 17;44(5):1083-5. doi: 10.1016/j.immuni.2016.05.003.
P-selectin glycoprotein ligand-1 (PSGL-1) and its glycostructural determinants facilitate responses to infection and cancer by promoting immune effector-cell trafficking into inflamed tissue. In this issue of Immunity, Tinoco et al. (2016) report homing-independent functions of PSGL-1 in immune checkpoint regulation and T cell effector activity, in models of chronic viral infection and melanoma.
P 选择素糖蛋白配体-1（PSGL-1）及其糖结构决定簇通过促进免疫效应细胞向炎症组织迁移，促进对感染和癌症的反应。在本期《免疫》杂志中，Tinoco 等人（2016）报道了 PSGL-1 在慢性病毒感染和黑色素瘤模型中的免疫检查点调节和 T 细胞效应活性中的非归巢功能。
