Tinoco Roberto, Otero Dennis C, Takahashi Amy A, Bradley Linda M
Infectious and Inflammatory Disease Center and National Cancer Institute (NCI)-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Research Institute, La Jolla, CA 92037, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA.
Infectious and Inflammatory Disease Center and National Cancer Institute (NCI)-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Research Institute, La Jolla, CA 92037, USA.
Trends Immunol. 2017 May;38(5):323-335. doi: 10.1016/j.it.2017.02.002. Epub 2017 Mar 2.
P-selectin glycoprotein ligand-1 (PSGL-1) has long been studied as an adhesion molecule involved in immune cell trafficking and is recognized as a regulator of many facets of immune responses by myeloid cells. PSGL-1 also regulates T cell migration during homeostasis and inflammatory settings. However, recent findings indicate that PSGL-1 can also negatively regulate T cell function. Because T cell differentiation is finely tuned by multiple positive and negative regulatory signals that appropriately scale the magnitude of the immune response, PSGL-1 has emerged as an important checkpoint during this process. We summarize what is known regarding PSGL-1 structure and function and highlight how it may act as an immune checkpoint inhibitor in T cells.
P-选择素糖蛋白配体-1（PSGL-1）长期以来一直作为一种参与免疫细胞运输的黏附分子进行研究，并被认为是髓系细胞免疫反应多个方面的调节因子。PSGL-1在稳态和炎症环境中也调节T细胞迁移。然而，最近的研究结果表明，PSGL-1也可以对T细胞功能产生负调节作用。由于T细胞分化受到多个正负调节信号的精细调控，这些信号适当地调节免疫反应的强度，因此PSGL-1已成为这一过程中的一个重要检查点。我们总结了关于PSGL-1结构和功能的已知信息，并强调了它如何可能作为T细胞中的一种免疫检查点抑制剂发挥作用。
