加拿大因纽特人群中F3-异前列腺素增加可能通过限制F2-异前列腺素生成而具有心脏保护作用。

Increased F3-Isoprostanes in the Canadian Inuit Population Could Be Cardioprotective by Limiting F2-Isoprostane Production.

作者信息

Alkazemi Dalal, Jackson Robert L, Chan Hing Man, Kubow Stan

机构信息

School of Dietetics and Human Nutrition (D.A., S.K.) and Centre for Indigenous Peoples' Nutrition and Environment (D.A.), McGill University, Ste-Anne-de-Bellevue, Québec, Canada H9X3V9; Department of Food Science and Nutrition (D.A.), College of Life Sciences, Kuwait University, Kuwait; Department of Pharmacology and Medicine (R.L.J.), Vanderbilt University, Nashville, Tennessee 37232-6602; and Center for Advanced Research in Environmental Genomics (H.M.C.), University of Ottawa, Ottawa, Ontario, Canada K1N 6N5.

出版信息

J Clin Endocrinol Metab. 2016 Sep;101(9):3264-71. doi: 10.1210/jc.2015-4096. Epub 2016 May 18.

DOI:10.1210/jc.2015-4096

PMID:27192695

Abstract

CONTEXT

F3-isoprostanes (F3-IsoPs), derived from peroxidation of eicosapentaenoic acid (C20:5n-3), could be cardioprotective by limiting production of F2-isoprostanes (F2-IsoPs), a cardiovascular disease risk factor.

OBJECTIVE

The objective of the study was to determine whether the n-3-polyunsaturated (PUFA)-rich Inuit diet is associated with a lower plasma ratio of F2-IsoPs to F3-IsoPs.

DESIGN

This was a cross-sectional observational study.

SETTING

The study was conducted in 36 Canadian Arctic Inuit communities.

PARTICIPANTS

Participants included a random subset (n = 233) of Inuit adults taken from a population-based survey.

MAIN OUTCOME MEASURES

Plasma F2-IsoPs and F3-IsoPs, cardiometabolic risk factors (blood lipids, C-reactive protein, blood pressure, fasting glucose) and markers of dietary exposure (erythrocyte n-3 and n-6 PUFA, blood levels of Se, mercury, polychlorinated biphenyls) were measured.

RESULTS

Inuit aged 40 years old and older vs younger Inuit showed higher concentrations of plasma F3-IsoPs and erythrocyte n-3 PUFA and lower plasma F2-IsoPs concentrations despite having higher blood lipids, fasting glucose, systolic blood pressure, and percentage body fat. Plasma F3-IsoPs were not associated with any cardiometabolic measures. When subjects were categorized into tertiles according to total n-3 PUFA erythrocyte concentrations, F3-IsoPs increased with increasing tertiles, whereas the F2-IsoP to F3-IsoP ratio was lowest at the highest n-3 tertile. The F2-IsoP to F3-IsoP ratio was significantly predicted by C20:5n-3 (β= -.365, P = .002); C20:4n-6:C20:5n-3 (β = .056, P = .006), blood mercury (β = -.812, P =.015), blood Se (β = -1.95, P = .015), and smoking (β = .745, P = .025).

CONCLUSIONS

Plasma F3-IsoPs were not associated with cardiometabolic risk factors previously seen with F2-IsoPs. Higher n-3 fatty acid status was associated with lower plasma F2-IsoPs and higher plasma F3-IsoPs, which provides partial explanation to the cardioprotective effects of the n-3 PUFA-rich Inuit diet.

摘要

背景

F3-异前列腺素（F3-IsoPs）由二十碳五烯酸（C20:5n-3）过氧化产生，通过限制心血管疾病风险因素F2-异前列腺素（F2-IsoPs）的生成，可能具有心脏保护作用。

目的

本研究旨在确定富含n-3多不饱和脂肪酸（PUFA）的因纽特人饮食是否与较低的血浆F2-IsoPs与F3-IsoPs比值相关。

设计

这是一项横断面观察性研究。

地点

该研究在36个加拿大北极因纽特人社区进行。

参与者

参与者包括从一项基于人群的调查中随机抽取的因纽特成年人子集（n = 233）。

主要观察指标

测量血浆F2-IsoPs和F3-IsoPs、心脏代谢风险因素（血脂、C反应蛋白、血压、空腹血糖）以及饮食暴露标志物（红细胞n-3和n-6 PUFA、血液中硒、汞、多氯联苯水平）。

结果

40岁及以上的因纽特人相较于年轻因纽特人，尽管血脂、空腹血糖、收缩压和体脂百分比更高，但血浆F3-IsoPs浓度和红细胞n-3 PUFA更高，而血浆F2-IsoPs浓度更低。血浆F3-IsoPs与任何心脏代谢指标均无关联。当根据红细胞总n-3 PUFA浓度将受试者分为三分位数时，F3-IsoPs随三分位数增加而升高，而F2-IsoP与F3-IsoP比值在n-3最高三分位数时最低。F2-IsoP与F3-IsoP比值由C20:5n-3（β = -.365，P = .002）、C20:4n-6:C20:5n-3（β = .056，P = .006）、血液汞含量（β = -.812，P = .015）、血液硒含量（β = -1.95，P = .015）和吸烟情况（β = .745，P = .025）显著预测。