Williams Glyn, Howard Richard
Department of Anaesthesia, Great Ormond Street Hospital For Children NHS Foundation Trust, Great Ormond Street, London, WC1N 3JH, UK.
Paediatr Drugs. 2016 Aug;18(4):243-50. doi: 10.1007/s40272-016-0179-z.
The awareness of complex regional pain syndrome (CRPS) in the pediatric population is increasing. The condition involves regional pain that is out of proportion to any initiating event (if there is one) and is associated with sensory, functional, autonomic, and inflammatory changes in the region of the pain. The signs and symptoms of CRPS can vary between patients and stage of the disease process. Like many chronic pain conditions, it is often associated with significant disability and a detrimental effect on quality of life. It has a complex pathophysiology that remains poorly understood but provides many potential targets for treatments. Management involves a biopsychosocial formulation that encompasses physical and psychological interventions alongside pharmacological strategies. We review the current evidence for the treatment of this condition in children, with particular reference to pharmacological management.
小儿群体对复杂性区域疼痛综合征（CRPS）的认识正在提高。该病症涉及与任何引发事件（若有）不成比例的局部疼痛，并伴有疼痛区域的感觉、功能、自主神经和炎症变化。CRPS的体征和症状在不同患者及疾病进程阶段会有所不同。与许多慢性疼痛病症一样，它常伴有严重残疾并对生活质量产生不利影响。其病理生理机制复杂，目前仍知之甚少，但为治疗提供了许多潜在靶点。治疗包括生物心理社会模式，涵盖物理和心理干预以及药物治疗策略。我们回顾了目前关于儿童CRPS治疗的证据，特别提及药物治疗管理。
