环丙沙星治疗耐甲氧西林金黄色葡萄球菌感染或定植。
Ciprofloxacin therapy for methicillin-resistant Staphylococcus aureus infections or colonizations.
作者信息
Smith S M, Eng R H, Tecson-Tumang F
机构信息
Microbiology Section, Veterans Administration Medical Center, East Orange, New Jersey 07019.
出版信息
Antimicrob Agents Chemother. 1989 Feb;33(2):181-4. doi: 10.1128/AAC.33.2.181.
Thirty patients were treated for colonization or for skin and soft tissue infections caused by methicillin-resistant Staphylococcus aureus. Three treatment regimens were evaluated, each progressively more aggressive. Our regimen was 750 mg of ciprofloxacin twice daily for 5 days, the second regimen was 750 mg of ciprofloxacin twice daily for 10 to 14 days, and the final regimen was 750 mg of ciprofloxacin twice daily plus 300 mg of rifampin twice daily for 21 days. It appears that ciprofloxacin alone produced an initial eradication rate in at least one site in 50% of the patients, regardless of whether the treatment was for 5 or up to 14 days. All of the patients with eradication became recolonized within 1 week posttherapy. When rifampin was combined with ciprofloxacin, the eradication rate was 100% when the isolates were susceptible to both agents, and these patients remained free of methicillin-resistant S. aureus at 1-week and 1-month follow-ups.
30名患者因耐甲氧西林金黄色葡萄球菌定植或皮肤及软组织感染接受治疗。评估了三种治疗方案，每种方案的激进程度依次增加。我们的方案是每日两次服用750毫克环丙沙星，共5天；第二种方案是每日两次服用750毫克环丙沙星，共10至14天；最后一种方案是每日两次服用750毫克环丙沙星加每日两次服用300毫克利福平，共21天。似乎单独使用环丙沙星时，无论治疗5天还是长达14天，至少在50%的患者中，有一个部位实现了初始根除率。所有实现根除的患者在治疗后1周内再次定植。当利福平与环丙沙星联合使用时，若分离株对两种药物均敏感，根除率为100%，且这些患者在1周和1个月随访时未再感染耐甲氧西林金黄色葡萄球菌。
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