环丙沙星、培氟沙星和万古霉素联合利福平在耐甲氧西林金黄色葡萄球菌慢性骨髓炎大鼠模型中的比较疗效。
Comparative efficacies of ciprofloxacin, pefloxacin, and vancomycin in combination with rifampin in a rat model of methicillin-resistant Staphylococcus aureus chronic osteomyelitis.
作者信息
Dworkin R, Modin G, Kunz S, Rich R, Zak O, Sande M
机构信息
University of California, San Francisco.
出版信息
Antimicrob Agents Chemother. 1990 Jun;34(6):1014-6. doi: 10.1128/AAC.34.6.1014.
Abstract
The efficacies of the quinolones ciprofloxacin and pefloxacin alone and in combination with rifampin were compared with those of vancomycin alone and in combination with rifampin in a rat model of chronic osteomyelitis caused by methicillin-resistant Staphylococcus aureus. Neither the quinolones nor vancomycin alone was effective in reducing titers of organisms in bone after therapy, while rifampin alone was effective. All combination regimens with rifampin were more effective than the regimen with rifampin alone was, although these differences did not achieve statistical significance. Rifampin-resistant isolates were detected rarely. Quinolone-rifampin combination regimens may offer a nonparenteral option for the treatment of chronic osteomyelitis caused by methicillin-resistant S. aureus.
摘要
在耐甲氧西林金黄色葡萄球菌引起的慢性骨髓炎大鼠模型中，比较了喹诺酮类药物环丙沙星和培氟沙星单独使用以及与利福平联合使用的疗效，与万古霉素单独使用以及与利福平联合使用的疗效。治疗后，喹诺酮类药物和万古霉素单独使用均不能有效降低骨内细菌滴度，而利福平单独使用则有效。所有含利福平的联合治疗方案均比利福平单药治疗方案更有效，尽管这些差异未达到统计学意义。很少检测到耐利福平的分离株。喹诺酮-利福平联合治疗方案可能为耐甲氧西林金黄色葡萄球菌引起的慢性骨髓炎提供一种非肠道给药的治疗选择。
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