Rouse M S, Wilcox R M, Henry N K, Steckelberg J M, Wilson W R
Mayo Clinic and Foundation, Mayo Medical School, Rochester, Minnesota 55905.
Antimicrob Agents Chemother. 1990 Feb;34(2):273-6. doi: 10.1128/AAC.34.2.273.
Ciprofloxacin or rifampin was significantly (P less than 0.05) more effective than vancomycin or the combination of vancomycin plus gentamicin for the treatment of Staphylococcus epidermidis experimental endocarditis. There were no significant differences in efficacy among any of the combinations of antimicrobial agents that included ciprofloxacin or rifampin. One animal treated with rifampin alone and one treated with the combination of vancomycin, rifampin, and gentamicin were found to be infected with rifampin-resistant strains of S. epidermidis during therapy. Resistant subpopulations of S. epidermidis were not detected during therapy with any other antimicrobial agent used alone or in combination. Ciprofloxacin alone or in combination with rifampin was effective therapy against S. epidermidis experimental endocarditis.
环丙沙星或利福平在治疗表皮葡萄球菌实验性心内膜炎方面比万古霉素或万古霉素加庆大霉素的组合显著更有效（P小于0.05）。在包括环丙沙星或利福平的任何抗菌药物组合之间，疗效没有显著差异。在治疗期间，发现一只单独接受利福平治疗的动物和一只接受万古霉素、利福平及庆大霉素联合治疗的动物感染了对利福平耐药的表皮葡萄球菌菌株。在用任何其他单独使用或联合使用的抗菌药物治疗期间，均未检测到表皮葡萄球菌的耐药亚群。单独使用环丙沙星或与利福平联合使用是治疗表皮葡萄球菌实验性心内膜炎的有效疗法。
