入院时低白蛋白血症预示着危重症儿童的不良预后。
Hypoalbuminaemia at admission predicts the poor outcomes in critically ill children.
作者信息
Kittisakmontri Kulnipa, Reungrongrat Sanit, Lao-Araya Mongkol
机构信息
Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
出版信息
Anaesthesiol Intensive Ther. 2016;48(3):158-61. doi: 10.5603/AIT.a2016.0028. Epub 2016 May 20.
BACKGROUND
Hypoalbuminaemia at admission is a common finding in patients admitted to the Paediatric Intensive Care Unit (PICU) and it is thought that this may predict morbidity and mortality.
METHODS
A retrospective study was conducted in the tertiary hospital. The medical records of critically ill children were reviewed. The data were analyzed for the prevalence of hypoalbuminaemia and outcomes.
RESULTS
Two hundred and two patients were included in the analysis. The incidence of hypoalbuminaemia at admission was 57.9%. These patients had a mortality rate 4 times greater (adjusted odds ratio 3.8; 95% CI: 1.4-10.0), a longer length of PICU stay (8.6 vs. 6.7 days, P = 0.04) and a longer period on a ventilator (5.9 vs. 3.9 days, P = 0.04) than patients with normal albumin levels.
CONCLUSIONS
Hypoalbuminaemia at admission was a predictive factor of poor outcome in critically ill children. It is associated with a higher mortality, a longer length of stay in the PICU, as well as longer ventilator use.
背景
入院时低白蛋白血症在儿科重症监护病房（PICU）收治的患者中是常见现象，人们认为这可能预示着发病和死亡情况。
方法
在一家三级医院进行了一项回顾性研究。对危重症儿童的病历进行了审查。分析了低白蛋白血症的患病率及相关结果。
结果
202例患者纳入分析。入院时低白蛋白血症的发生率为57.9%。与白蛋白水平正常的患者相比，这些患者的死亡率高出4倍（校正比值比3.8；95%置信区间：1.4 - 10.0），PICU住院时间更长（8.6天对6.7天，P = 0.04），使用呼吸机的时间更长（5.9天对3.9天，P = 0.04）。
结论
入院时低白蛋白血症是危重症儿童预后不良的一个预测因素。它与更高的死亡率、更长的PICU住院时间以及更长时间使用呼吸机有关。
Zotero 插件