Ertan Olcay Esra Sargın, Gökçe Onur, Bal Cengiz, Kocaturk Evin, Ertan Orçun, Mutluay Rüya
Eskisehir Osmangazi University School of Medicine Department of Internal Medicine Eskisehir Turkey.
Eskisehir Yunus Emre State Hospital Department of Critical Care Eskisehir Turkey.
J Acute Med. 2024 Dec 1;14(4):152-159. doi: 10.6705/j.jacme.202412_14(4).0003.
Acute kidney injury (AKI) is a significant concern in critically ill patients, with mortality and morbidity implications. The serum uric acid-to-albumin ratio has been proposed as a potential prognostic marker for patients with and without AKI. This study aimed to investigate the relationship between this ratio and 28-day mortality in these patient groups.
A retrospective study was conducted on critically ill patients aged over 18, hospitalized in the internal medicine ICU at Osmangazi University, Eskisehir, Turkey, from May 2020 to November 2021. Patients were categorized based on the presence or absence of AKI. The primary outcome was 28-day mortality. The serum uric acid-to-albumin ratio was calculated, and its prognostic value was assessed using Receiver Operating Curve (ROC) analysis.
Of the 1,016 patients, 449 had AKI. The mean age was 67.1 ± 15.27 years, with 53.9% being male. The serum uric acid-to-albumin ratio was found to have significant prognostic value in predicting 28-day mortality in both groups. In the overall study group, a ratio of 2.32 mg/g predicted 28-day mortality with 71.1% specificity and 58.3% sensitivity. For patients with AKI, a ratio of 3.59 mg/g predicted mortality with 85.3% specificity and 44% sensitivity. For those without AKI, a ratio of 2.28 mg/g predicted mortality with 84.1% specificity and 39.3% sensitivity.
The serum uric acid-to-albumin ratio is a valuable prognostic tool for predicting 28-day mortality in critically ill patients, irrespective of AKI status. Incorporating this low-cost biomarker into scoring systems could enhance patient management and outcome predictions.
急性肾损伤（AKI）是重症患者的一个重大问题，涉及死亡率和发病率。血清尿酸与白蛋白比值已被提议作为有无AKI患者的潜在预后标志物。本研究旨在探讨该比值与这些患者群体28天死亡率之间的关系。
对2020年5月至2021年11月在土耳其埃斯基谢希尔奥斯曼加齐大学内科重症监护病房住院的18岁以上重症患者进行回顾性研究。根据是否存在AKI对患者进行分类。主要结局是28天死亡率。计算血清尿酸与白蛋白比值，并使用受试者工作特征曲线（ROC）分析评估其预后价值。
1016例患者中，449例患有AKI。平均年龄为67.1±15.27岁，男性占53.9%。发现血清尿酸与白蛋白比值在预测两组患者28天死亡率方面具有显著的预后价值。在整个研究组中，2.32mg/g的比值预测28天死亡率的特异性为71.1%，敏感性为
