Isbister J P, Cooper D A, Blake H M, Biggs J C, Dixon R A, Penny R
Am J Med. 1978 Mar;64(3):434-40. doi: 10.1016/0002-9343(78)90229-2.
Four patients with lymphoproliferative disease with immunoglobulin M lambda (IgMlambda) monoclonal proteins and severe autoimmune hemolytic anemia are described. These patients had many features in common that may warrant their recognition as a specific entity within the lymphoproliferative spectrum. In each case, a wide thermal range low titer cold agglutinin was present. The association of cold autoimmune hemolytic anemia with IgMlambda monoclonal protein and lymphoproliferative disease is unusual. The literature on IgM monoclonal proteins associated with lymphoproliferative disease is reviewed with emphasis on the presence of direct antiglobulin test positive autoimmune hemolytic anemia.
本文描述了4例患有免疫球蛋白Mλ（IgMλ）单克隆蛋白血症及严重自身免疫性溶血性贫血的淋巴增殖性疾病患者。这些患者具有许多共同特征，可能有必要将其视为淋巴增殖性疾病谱中的一种特定疾病。在每例患者中，均存在宽热幅低滴度冷凝集素。冷凝集素介导的自身免疫性溶血性贫血与IgMλ单克隆蛋白血症及淋巴增殖性疾病相关的情况并不常见。本文对与淋巴增殖性疾病相关的IgM单克隆蛋白血症的文献进行了综述，重点关注直接抗球蛋白试验阳性的自身免疫性溶血性贫血的存在情况。
