分子控制机制的设计与基因表达的需求。
Design of molecular control mechanisms and the demand for gene expression.
作者信息
Savageau M A
出版信息
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5647-51. doi: 10.1073/pnas.74.12.5647.
Abstract
Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].
摘要
当在生物体的自然环境中对受调控的结构基因的表达需求较低时，选择由阻遏蛋白进行调控的机制。当对受调控的结构基因的表达需求较高时，则选择由激活蛋白进行调控。这些一般性结论对于将生理功能与包括可阻遏生物合成途径、可诱导生物合成酶、可诱导耐药性和原噬菌体诱导以及可诱导分解代谢途径在内的多种系统中的潜在分子决定因素相关联很有用，此前曾报道过该预测的一个特殊情况适用于可诱导分解代谢途径[萨维奇奥，M. A.（1974年）《美国国家科学院院刊》71，2453 - 2455]。
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