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相似文献

1
Design of molecular control mechanisms and the demand for gene expression.分子控制机制的设计与基因表达的需求。
Proc Natl Acad Sci U S A. 1977 Dec;74(12):5647-51. doi: 10.1073/pnas.74.12.5647.
2
Significance of autogenously regulated and constitutive synthesis of regulatory proteins in repressible biosynthetic systems.
Nature. 1975 Nov 20;258(5532):208-14. doi: 10.1038/258208a0.
3
Comparison of classical and autogenous systems of regulation in inducible operons.
Nature. 1974 Dec 13;252(5484):546-9. doi: 10.1038/252546a0.
4
Quantitative model for gene regulation by lambda phage repressor.λ噬菌体阻遏物基因调控的定量模型。
Proc Natl Acad Sci U S A. 1982 Feb;79(4):1129-33. doi: 10.1073/pnas.79.4.1129.
5
Histidine regulation in Salmonella typhimurium: an activator attenuator model of gene regulation.鼠伤寒沙门氏菌中的组氨酸调控：一种基因调控的激活子-衰减子模型
Proc Natl Acad Sci U S A. 1975 Sep;72(9):3453-7. doi: 10.1073/pnas.72.9.3453.
6
Split-operon control of a prophage gene.原噬菌体基因的分裂操纵子控制
Proc Natl Acad Sci U S A. 1970 Feb;65(2):331-6. doi: 10.1073/pnas.65.2.331.
7
Mechanisms for the regulation of enzyme synthesis.酶合成的调控机制。
J Gen Microbiol. 1971 Mar;65(3):8.
8
Gene regulation in bacteria: a new conception of the operon.
Curr Mod Biol. 1968 Sep-Oct;2(4):189-96.
9
Enzyme induction (third of three parts).
N Engl J Med. 1976 Mar 18;294(12):646-51. doi: 10.1056/NEJM197603182941206.
10
[Repression of the enzyme inducible syntheses in Escherichia coli K12 mutant with a deleted ptsH gene].[ptsH基因缺失的大肠杆菌K12突变体中酶诱导合成的抑制作用]
Mol Biol (Mosk). 1977 May-Jun;11(3):611-9.

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Activation-derepression synergy enables a bHLH network to coordinate a signal-specific fate response.激活-去抑制协同作用使一个bHLH网络能够协调特定信号的命运反应。
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2
Flexibility and sensitivity in gene regulation out of equilibrium.基因调控的非平衡态下的灵活性和敏感性。
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3
Competition and evolutionary selection among core regulatory motifs in gene expression control.基因表达调控中核心调控基序的竞争与进化选择。
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Conversion of into Mixotrophic CO Assimilation with Malate and Hydrogen Based on Recombinant Expression of 2-Oxoglutarate:Ferredoxin Oxidoreductase Using Adaptive Laboratory Evolution.基于2-氧戊二酸：铁氧化还原蛋白氧化还原酶的重组表达，利用适应性实验室进化将[具体内容缺失]转化为以苹果酸和氢气为基础的混合营养型CO同化作用。
Microorganisms. 2023 Jan 19;11(2):253. doi: 10.3390/microorganisms11020253.
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Optimal transcriptional regulation of dynamic bacterial responses to sudden drug exposures.优化细菌对突然药物暴露的动态反应的转录调控。
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6
Negative autoregulation controls size scaling in confined gene expression reactions.负自动调节控制受限基因表达反应中的大小缩放。
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7
Molecular switch architecture determines response properties of signaling pathways.分子开关结构决定信号通路的响应特性。
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The relation between crosstalk and gene regulation form revisited.重新探讨串扰与基因调控之间的关系。
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9
The Design Principles of Biochemical Timers: Circuits that Discriminate between Transient and Sustained Stimulation.生化定时器的设计原则：区分瞬态和持续刺激的电路。
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10
Effects of Population Dynamics on Establishment of a Restriction-Modification System in a Bacterial Host.人口动态对细菌宿主中限制-修饰系统建立的影响。
Molecules. 2019 Jan 7;24(1):198. doi: 10.3390/molecules24010198.

本文引用的文献

1
Selective absorption of stereo-isomers of amino-acids from loops of the small intestine of the rat.大鼠小肠肠袢对氨基酸立体异构体的选择性吸收。
Biochem J. 1951 Apr;48(4):426-9. doi: 10.1042/bj0480426.
2
The teleonomic significance of biosynthetic control mechanisms.生物合成控制机制的目的性意义。
Cold Spring Harb Symp Quant Biol. 1961;26:1-10. doi: 10.1101/sqb.1961.026.01.005.
3
The uptake of amino acids by isolated segments of rat intestine. II. A survey of affinity for uptake from rates of uptake and competition for uptake.大鼠肠道分离段对氨基酸的摄取。II. 根据摄取速率和摄取竞争对摄取亲和力的研究。
Biochim Biophys Acta. 1960 Sep 23;43:278-87. doi: 10.1016/0006-3002(60)90438-8.
4
Intestinal absorption of essential amino acids in man.人体对必需氨基酸的肠道吸收
Gastroenterology. 1967 May;52(5):837-45.
5
The kinetics of amino acid absorption and alteration of plasma composition of free amino acids after intestinal perfusion of amino acid mixtures.氨基酸混合物经肠道灌注后氨基酸吸收动力学及血浆游离氨基酸组成的变化
Am J Clin Nutr. 1967 Jan;20(1):24-33. doi: 10.1093/ajcn/20.1.24.
6
Intestinal sugar transport: ionic activation and chemical specificity.肠道糖转运：离子激活与化学特异性。
Biochim Biophys Acta. 1969 Jun 3;183(1):169-81. doi: 10.1016/0005-2736(69)90141-2.
7
Tryptophanase in diverse bacterial species.不同细菌物种中的色氨酸酶
J Bacteriol. 1969 Apr;98(1):167-71. doi: 10.1128/jb.98.1.167-171.1969.
8
New regulatory mutation affecting some of the tryptophan genes in Pseudomonas putida.影响恶臭假单胞菌中某些色氨酸基因的新调控突变。
J Bacteriol. 1971 May;106(2):331-8. doi: 10.1128/jb.106.2.331-338.1971.
9
Clear plaque mutants of phage P1.噬菌体P1的透明噬菌斑突变体
Virology. 1970 May;41(1):66-71. doi: 10.1016/0042-6822(70)90054-1.
10
The digestion and absorption of protein in man. 2. The form in which digested protein is absorbed.人体中蛋白质的消化与吸收。2. 消化后的蛋白质被吸收的形式。
Br J Nutr. 1970 Mar;24(1):241-58. doi: 10.1079/bjn19700024.

分子控制机制的设计与基因表达的需求。

Design of molecular control mechanisms and the demand for gene expression.

作者信息

Savageau M A

出版信息

Proc Natl Acad Sci U S A. 1977 Dec;74(12):5647-51. doi: 10.1073/pnas.74.12.5647.

DOI:10.1073/pnas.74.12.5647
PMID:271992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC431845/
Abstract

Regulation by a repressor protein is the mechanism selected when, in the organism's natural environment, there is low demand for expression of the regulated structural genes. Regulation by an activator protein is selected when there is high demand for expression of the regulated structural genes. These general conclusions are useful in relating physiological function to underlying molecular determinants in a wide variety of systems that includes repressible biosynthetic pathways, inducible biosynthetic enzymes, inducible drug resistance, and prophage induction, as well as inducible catabolic pathways, for which a special case of this prediction previously was reported [Savageau, M. A. (1974) Proc. Natl. Acad. Sci. USA 71, 2453-2455].

摘要

当在生物体的自然环境中对受调控的结构基因的表达需求较低时，选择由阻遏蛋白进行调控的机制。当对受调控的结构基因的表达需求较高时，则选择由激活蛋白进行调控。这些一般性结论对于将生理功能与包括可阻遏生物合成途径、可诱导生物合成酶、可诱导耐药性和原噬菌体诱导以及可诱导分解代谢途径在内的多种系统中的潜在分子决定因素相关联很有用，此前曾报道过该预测的一个特殊情况适用于可诱导分解代谢途径[萨维奇奥，M. A.（1974年）《美国国家科学院院刊》71，2453 - 2455]。