Wang Cuizhe, Ha Xiaodan, Li Wei, Xu Peng, Gu Yajuan, Wang Tingting, Wang Yan, Xie Jianxin, Zhang Jun
Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China.
Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China; The First Affiliated Hospital Clinical Laboratory, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China.
Mediators Inflamm. 2016;2016:7015620. doi: 10.1155/2016/7015620. Epub 2016 Apr 21.
In this paper, the researchers collected visceral adipose tissue from the Uygur population, which were divided into two groups: the normal control group (NC, n = 50, 18.0 kg/m(2) ≤ BMI ≤ 23.9 kg/m(2)) and the obese group (OB, n = 45, BMI ≥ 28 kg/m(2)), and then use real-time PCR to detect the mRNA expression level of key genes involved in inflammation signaling pathway. The findings suggest that, in obese status, the lower expression level of A2bAR, KLF4, and KLF15 of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.
在本文中,研究人员收集了维吾尔族人群的内脏脂肪组织,将其分为两组:正常对照组(NC,n = 50,18.0 kg/m²≤体重指数≤23.9 kg/m²)和肥胖组(OB,n = 45,体重指数≥28 kg/m²),然后使用实时定量聚合酶链反应检测炎症信号通路中关键基因的信使核糖核酸表达水平。研究结果表明,在肥胖状态下,维吾尔族人群内脏脂肪组织中A2bAR、KLF4和KLF15的较低表达水平可能与肥胖血脂异常诱导的炎症相关。