克鲁ppel样因子：削弱与恢复代谢途径

Pollak Nina M, Hoffman Matthew, Goldberg Ira J, Drosatos Konstantinos

School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane, QLD, Australia.

Metabolic Biology Laboratory, Center for Translational Medicine, Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA.

JACC Basic Transl Sci. 2018 Feb;3(1):132-156. doi: 10.1016/j.jacbts.2017.09.001. Epub 2018 Mar 1.

Krüppel-like factors (KLFs) are DNA-binding transcriptional factors that regulate various pathways that control metabolism and other cellular mechanisms. Various KLF isoforms have been associated with cellular, organ or systemic metabolism. Altered expression or activation of KLFs has been linked to metabolic abnormalities, such as obesity and diabetes, as well as with heart failure. In this review article we summarize the metabolic functions of KLFs, as well as the networks of different KLF isoforms that jointly regulate metabolism in health and disease.

Krüppel样因子（KLFs）是DNA结合转录因子，可调节控制代谢和其他细胞机制的各种途径。各种KLF亚型与细胞、器官或全身代谢有关。KLFs的表达改变或激活与代谢异常有关，如肥胖和糖尿病，以及心力衰竭。在这篇综述文章中，我们总结了KLFs的代谢功能，以及在健康和疾病中共同调节代谢的不同KLF亚型网络。