Motojima K, Goto S
Department of Biochemistry, Faculty of Pharmaceutical Science, Toho University, Funabashi, Japan.
Biochim Biophys Acta. 1989 Jun 1;1008(1):116-8. doi: 10.1016/0167-4781(89)90178-4.
cDNA clones encoding uricase have been isolated from a rabbit liver cDNA library. The nucleotide sequences of the cDNAs have been determined and those of the rat uricase cDNA have been revised. In all three uricases, the carboxy-terminal tripeptides are Ser-Arg/Lys-Leu sequences, which have recently been suggested as an essential element of peroxisomal targetting signals for many but not all peroxisomal proteins.
编码尿酸酶的cDNA克隆已从兔肝脏cDNA文库中分离出来。已确定了这些cDNA的核苷酸序列，并对大鼠尿酸酶cDNA的序列进行了修订。在所有三种尿酸酶中，羧基末端的三肽都是Ser-Arg/Lys-Leu序列，最近有人提出，对于许多但并非所有过氧化物酶体蛋白来说，该序列是过氧化物酶体靶向信号的一个基本元件。
