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N-酰基乙醇胺对脑损伤和神经退行性变中神经胶质细胞的调节作用

Glial Modulation by N-acylethanolamides in Brain Injury and Neurodegeneration.

作者信息

Herrera María I, Kölliker-Frers Rodolfo, Barreto George, Blanco Eduardo, Capani Francisco

机构信息

Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y TécnicasBuenos Aires, Argentina; Centro de Investigaciones en Psicología y Psicopedagogía, Facultad de Psicología, Universidad Católica ArgentinaBuenos Aires, Argentina.

Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires - Consejo Nacional de Investigaciones Científicas y Técnicas Buenos Aires, Argentina.

出版信息

Front Aging Neurosci. 2016 Apr 26;8:81. doi: 10.3389/fnagi.2016.00081. eCollection 2016.

DOI:10.3389/fnagi.2016.00081
PMID:27199733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4844606/
Abstract

Neuroinflammation involves the activation of glial cells and represents a key element in normal aging and pathophysiology of brain damage. N-acylethanolamides (NAEs), naturally occurring amides, are known for their pro-homeostatic effects. An increase in NAEs has been reported in vivo and in vitro in the aging brain and in brain injury. Treatment with NAEs may promote neuroprotection and exert anti-inflammatory actions via PPARα activation and/or by counteracting gliosis. This review aims to provide an overview of endogenous and exogenous properties of NAEs in neuroinflammation and to discuss their interaction with glial cells.

摘要

神经炎症涉及胶质细胞的激活，是正常衰老和脑损伤病理生理学中的关键因素。N-酰基乙醇胺（NAEs）是天然存在的酰胺，以其促稳态作用而闻名。在衰老大脑和脑损伤的体内和体外研究中均报道了NAEs的增加。用NAEs治疗可能通过激活PPARα和/或通过对抗胶质细胞增生来促进神经保护并发挥抗炎作用。本综述旨在概述NAEs在神经炎症中的内源性和外源性特性，并讨论它们与胶质细胞的相互作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca6/4844606/b1b850fe948d/fnagi-08-00081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca6/4844606/39f46f2c9715/fnagi-08-00081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca6/4844606/b1b850fe948d/fnagi-08-00081-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca6/4844606/39f46f2c9715/fnagi-08-00081-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5ca6/4844606/b1b850fe948d/fnagi-08-00081-g002.jpg

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