体重对多囊卵巢综合征患者血清同型半胱氨酸水平的影响：一项病例对照研究。
Effect of body weight on serum homocysteine level in patients with polycystic ovarian syndrome: A case control study.
作者信息
I Al-Gareeb Ali, Abd Al-Amieer Wafaa Salah, M Alkuraishy Hayder, J Al-Mayahi Thabat
机构信息
Department of Clinical Pharmacology and Therapeutics, College of Medicine, Al- Mustansiriya University, Baghdad, Iraq.
Department of Obstetrics and Gynecology, Al-Kadhymia Teaching Hospital, Baghdad, Iraq.
出版信息
Int J Reprod Biomed. 2016 Feb;14(2):81-8.
BACKGROUND
Polycystic ovarian syndrome (PCOS) represent one of the common endocrine disorders which influence around 8% of reproductive women whom usually suffering from obesity and increase cardiovascular risk. Serum homocysteine levels are associated with bad impact on endothelial functions and considered as an independent risk factor for cardiovascular disease.
OBJECTIVE
The aim was to study the level of plasma homocysteine in obese and non-obese Iraqi patients with PCOS.
MATERIALS AND METHODS
This study was carried out on 207 women. Of theme, 101 women with PCOS and 106 PCOS- free women served as controls. Blood sample was taken from each participant on the 2(nd) day of menstruation morning after an overnight fasting. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), free testosterone and androstenedione were measured. Moreover, total lipid profile and plasma homocysteine levels were measured in both groups.
RESULTS
Sixty percent of PCOS women were overweight or obese and 56% of them had a waist circumference >88cm. Moreover plasma homocysteine concentrations were found to be higher in patients with PCOS (11.5±5.41μmol/L) as compared with control (8.10±1.89 μmol/L) (p<0.002). Furthermore the homocysteine concentrations were 13.19±5.97 μmol/L and 9.38±2.99 μmol/L in both obese and normal-weight PCOS women respectively which was significantly higher than obese (p<0.002) and normal-weight (p<0.004) control women.
CONCLUSION
Increase in body weight is not an independent risk factor to increase plasma homocysteine levels in PCOS women.
背景
多囊卵巢综合征（PCOS）是常见的内分泌疾病之一，影响约8%的育龄女性，这些女性通常肥胖且心血管疾病风险增加。血清同型半胱氨酸水平对血管内皮功能有不良影响，被认为是心血管疾病的独立危险因素。
目的
研究肥胖和非肥胖的伊拉克PCOS患者血浆同型半胱氨酸水平。
材料与方法
本研究对207名女性进行。其中，101名PCOS女性和106名无PCOS女性作为对照。每位参与者在月经周期第2天早晨空腹后采集血样。检测血清卵泡刺激素（FSH）、黄体生成素（LH）、游离睾酮和雄烯二酮水平。此外，两组均检测总血脂谱和血浆同型半胱氨酸水平。
结果
60%的PCOS女性超重或肥胖，其中56%的腰围>88cm。此外，发现PCOS患者的血浆同型半胱氨酸浓度（11.5±5.41μmol/L）高于对照组（8.10±1.89μmol/L）（p<0.002）。此外，肥胖和正常体重的PCOS女性的同型半胱氨酸浓度分别为13.19±5.97μmol/L和9.38±2.99μmol/L，显著高于肥胖（p<0.002）和正常体重（p<0.004）的对照女性。
结论
体重增加不是PCOS女性血浆同型半胱氨酸水平升高的独立危险因素。
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