Bhushan Rashmi, Sinha Parul
Department of Obstetrics & Gynaecology, Era's Lucknow Medical College, Lucknow, Uttar Pradesh, India.
Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, Raebareli, Uttar Pradesh, India.
J Hum Reprod Sci. 2022 Jan-Mar;15(1):34-41. doi: 10.4103/jhrs.jhrs_147_21. Epub 2022 Mar 31.
Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting women in reproductive age group. The interrelationship of serum homocysteine, homoeostatic assessment of insulin resistance (HOMA-IR) and body mass index amongst overweight, obese and non-obese PCOS patients is not fully established.
We aimed to study the correlation of serum homocysteine levels and hyperinsulinaemia with body mass index (BMI) in PCOS patients.
This was a case-control study in which 35 women with PCOS and 35 non-PCOS women acting as controls were enrolled.
Cases were identified by Rotterdam's criteria. (IR) indices, HOMA determination and serum homocysteine levels were determined and their correlation with BMI was studied.
Student's -test and analysis of variance test were used for statistical analysis. The Pearson correlation coefficient was then used to estimate the correlation.
On overall evaluation, a significant positive correlation of fasting insulin, HOMA-IR and serum homocysteine) was observed ( < 0.05), however, on evaluating the correlation of these markers independently in cases and controls, only fasting insulin and HOMA-IR showed a significant correlation. In a multivariate model where PCOS was considered a dependent variable with age, fasting glucose, HOMA-IR, serum homocysteine and body mass index as the independent variables, only serum homocysteine levels were found to be significantly associated with the dependent variable (odds ratio = 1.172; 95% confidence interval = 1.032-1.330).
PCOS women had significantly higher mean fasting glucose, fasting insulin, HOMA-IR and homocysteine levels as compared to non-PCOS controls. Mean HOMA-IR, homocysteine and fasting insulin levels showed a significant incremental trend with increasing BMI category in overall evaluation as well as in cases and controls independently.
多囊卵巢综合征（PCOS）是影响育龄期女性的最常见内分泌疾病之一。超重、肥胖和非肥胖PCOS患者血清同型半胱氨酸、胰岛素抵抗稳态评估（HOMA-IR）和体重指数之间的相互关系尚未完全明确。
我们旨在研究PCOS患者血清同型半胱氨酸水平和高胰岛素血症与体重指数（BMI）之间的相关性。
这是一项病例对照研究，纳入了35例PCOS女性和35例作为对照的非PCOS女性。
根据鹿特丹标准确定病例。测定胰岛素抵抗（IR）指数、HOMA并检测血清同型半胱氨酸水平，研究它们与BMI的相关性。
采用学生t检验和方差分析进行统计分析。然后用Pearson相关系数估计相关性。
总体评估时，观察到空腹胰岛素、HOMA-IR和血清同型半胱氨酸之间存在显著正相关（P<0.05），然而，在病例组和对照组中分别独立评估这些指标的相关性时，只有空腹胰岛素和HOMA-IR显示出显著相关性。在一个多变量模型中，将PCOS视为因变量，年龄、空腹血糖、HOMA-IR、血清同型半胱氨酸和体重指数作为自变量，发现只有血清同型半胱氨酸水平与因变量显著相关（比值比=1.172；95%置信区间=1.032-1.330）。
与非PCOS对照组相比，PCOS女性的平均空腹血糖、空腹胰岛素、HOMA-IR和同型半胱氨酸水平显著更高。总体评估以及病例组和对照组分别独立评估时，平均HOMA-IR、同型半胱氨酸和空腹胰岛素水平均随BMI类别增加呈显著上升趋势。
