Okamoto M, Sakai T, Hayashi K
Department of Agricultural Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Biosystems. 1989;22(2):155-62. doi: 10.1016/0303-2647(89)90043-9.
We previously showed with computer simulations that cyclic enzyme systems have the reliability of ON-OFF types of operation (McCulloch-Pitts' neuronic equation) and the applicability for a switching circuit in a biocomputer. The switching time was inevitably determined in accordance with the difference in amount between two inputs of the system. This characteristic is, however, a disadvantage for practical use of a switching device; we need to improve the system in order for the switching time to optionally be changed. We shall present here how to turn on (off) the switch independently of the modes of two inputs. By introducing pulse perturbation, we could optionally set up the switching time of a cyclic enzyme system (biochemical switching device).
我们之前通过计算机模拟表明，循环酶系统具有开-关型操作的可靠性（麦卡洛克-皮茨神经元方程）以及在生物计算机中作为开关电路的适用性。开关时间不可避免地取决于系统两个输入量之间的差异。然而，这一特性对于开关装置的实际应用来说是一个缺点；我们需要改进该系统，以便能够随意改变开关时间。我们将在此介绍如何独立于两个输入的模式来开启（关闭）开关。通过引入脉冲扰动，我们能够随意设定循环酶系统（生化开关装置）的开关时间。
