循环酶系统的转换机制：作为“化学二极管”的作用。

Switching mechanism of a cyclic enzyme system: role as a "chemical diode".

作者信息

Okamoto M, Sakai T, Hayashi K

机构信息

Department of Agricultural Chemistry, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.

出版信息

Biosystems. 1987;21(1):1-11. doi: 10.1016/0303-2647(87)90002-5.

DOI:10.1016/0303-2647(87)90002-5

PMID:3689885

Abstract

We previously showed with computer simulations that cyclic enzyme systems play a role in metabolic switching events. In the present study, the detailed switching mechanism was investigated by clarifying the relationship between the switching mode and the phase-difference of two sinusoidal inputs to the cyclic enzyme system. The switching time could be predicted theoretically. Half-wave and full-wave rectifications were observed when the phase-difference of two sinusoidal inputs is equal to pi. This result indicates the possibility that this cyclic enzyme system is available for use as a switching circuit (biochip) in a bio-computer.

摘要

我们之前通过计算机模拟表明，循环酶系统在代谢转换事件中发挥作用。在本研究中，通过阐明循环酶系统两个正弦输入的转换模式与相位差之间的关系，对详细的转换机制进行了研究。转换时间可以从理论上进行预测。当两个正弦输入的相位差等于π时，观察到了半波和全波整流。这一结果表明，这种循环酶系统有可能用作生物计算机中的开关电路（生物芯片）。