通过更好地理解双稳性行为来微调生物开关。
Tweaking biological switches through a better understanding of bistability behavior.
作者信息
Chatterjee Anushree, Kaznessis Yiannis N, Hu Wei-Shou
机构信息
Department of Chemical Engineering and Materials Science, University of Minnesota, 421 Washington Avenue SE, Minneapolis, MN 55455-0132, USA.
出版信息
Curr Opin Biotechnol. 2008 Oct;19(5):475-81. doi: 10.1016/j.copbio.2008.08.010. Epub 2008 Oct 1.
Abstract
Many biological events are binary. The switch between mutually exclusive OFF to ON state in response to a stimulus is frequently mediated by a control circuit with a positive and/or a negative feedback. Such a system typically exhibits hysteresis with its switching ON and OFF stimulus levels dependent on the current state of the system. The system can be shown to be bistable both experimentally and mathematically. Work to synthesize such switches by combining natural or engineered components has begun to illustrate the potential of such control circuits in many areas of applications.
摘要
许多生物事件都是二元的。响应刺激时，从相互排斥的关闭状态到开启状态的切换通常由具有正反馈和/或负反馈的控制电路介导。这样的系统通常表现出滞后现象，其开启和关闭刺激水平取决于系统的当前状态。该系统在实验和数学上都可证明是双稳态的。通过组合天然或工程组件来合成此类开关的工作已开始说明这种控制电路在许多应用领域的潜力。
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