[外周抗胆碱作用——西多芬的作用之一]
[Peripheral cholinolytic action--one of the effects of sidnofen].
作者信息
Samonina G E, Mandriko E V
出版信息
Biull Eksp Biol Med. 1989 Apr;107(4):449-51.
PMID:2720163
Abstract
Intravenous bolus injection of sydnophen (0.002-20 micrograms/kg) resulted in decrease or complete abolition of bradycardia induced by electrical stimulation of vagal peripheral end of anesthetized cats. The cholinolytic effects are dose-dependent. The small dose of sydnophen (0.002 micrograms/kg) which wasn't able to cause any alteration of EEG, heart rate and arterial pressure induced decrease of vagal bradycardia.
摘要
静脉推注西多芬（0.002 - 20微克/千克）可导致麻醉猫迷走神经外周端电刺激所诱发的心动过缓减弱或完全消失。其抗胆碱作用呈剂量依赖性。小剂量的西多芬（0.002微克/千克）虽未引起脑电图、心率和动脉压的任何改变，但却能减轻迷走神经介导的心动过缓。
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