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[辛多芬与咖啡因对骨骼肌收缩时动脉血压反射性变化的影响]

[Effect of sydnophen and caffeine on reflex shifts in arterial pressure arising during skeletal muscle contraction].

作者信息

Medvedev O S, Stepochkina N A

出版信息

Farmakol Toksikol. 1977 Jan-Feb;40(1):50-3.

PMID:852546
Abstract

The influence of sydnophen (5-20 mg/kg) and of caffein (10-40 mg/kg) on the pressor reaction of the arterial pressure, provoked by contraction of skeletal muscles following stimulation of the anterior spinal cord roots (L6, L7, S1) was investigated in 17 tests set up on decerebrated non-narcotized cats. The intraveonus injection of sydnophen was attended by a fall of the arterial pressure and inhibition of the pressor reflex. Caffein reduced the intensity of the pressor reflex to a lesser extent and did not modify the initial level of the arterial pressure.

摘要

在17项针对去大脑未麻醉猫进行的实验中,研究了辛多芬(5 - 20毫克/千克)和咖啡因(10 - 40毫克/千克)对刺激脊髓前根(L6、L7、S1)后骨骼肌收缩所引发的动脉血压升压反应的影响。静脉注射辛多芬会导致动脉血压下降并抑制升压反射。咖啡因在较小程度上降低了升压反射的强度,且未改变动脉血压的初始水平。

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