大鼠妊娠晚期亚急性给予阿片类药物对分娩的启动、持续时间和结局以及母体催产素和精氨酸加压素水平的影响。

Effects of subacute opioid administration during late pregnancy in the rat on the initiation, duration and outcome of parturition and maternal levels of oxytocin and arginine vasopressin.

Evans R G, Olley J E, Rice G E, Abrahams J M

Department of Pharmacology, Monash University, Clayton, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1989 Mar;16(3):169-78. doi: 10.1111/j.1440-1681.1989.tb01541.x.

Abstract

The effects, on parturition in the rat, of subacute and acute opioid administration were studied. Further experiments investigated the role of modulation of maternal plasma and pituitary oxytocin (OXY) and arginine vasopressin (AVP) levels in these effects. 2. Subacute opioid (M320, buprenorphine or bremazocine) administration prolonged the gestation of rats. This was accompanied by toxic effects on the offspring. Acute subcutaneous (s.c.) M320 (10 micrograms/kg) administration was accompanied by prolonged gestation without toxic effects. 3. Subacute M320 (10 micrograms/kg, s.c., twice daily) treatment was accompanied by increased interbirth intervals in parturient rats. 4. Maternal OXY but not AVP release, as assessed by measurement of plasma and pituitary immunoreactivity, was elevated during and up to 1 h after the completion of parturition. Subacute M320 treatment did not inhibit this elevated OXY release.

摘要

研究了亚急性和急性给予阿片类药物对大鼠分娩的影响。进一步的实验探讨了母体血浆和垂体中催产素（OXY）及精氨酸加压素（AVP）水平的调节在这些影响中的作用。2. 亚急性给予阿片类药物（M320、丁丙诺啡或布瑞马唑辛）会延长大鼠的妊娠期。这伴随着对后代的毒性作用。急性皮下注射M320（10微克/千克）会延长妊娠期且无毒性作用。3. 亚急性给予M320（10微克/千克，皮下注射，每日两次）会使分娩大鼠的产仔间隔延长。4. 通过测量血浆和垂体中的免疫反应性评估，母体OXY的释放而非AVP的释放在分娩期间及分娩结束后1小时内升高。亚急性M320治疗并未抑制这种升高的OXY释放。