黄酮类化合物及相关类似物的抗抑郁作用及其机制。

Antidepressant-like effects and mechanisms of flavonoids and related analogues.

机构信息

Food and Pharmacy College, Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, Zhejiang, Zhoushan, 316022, PR China.

出版信息

Eur J Med Chem. 2016 Oct 4;121:47-57. doi: 10.1016/j.ejmech.2016.05.026. Epub 2016 May 12.

DOI:10.1016/j.ejmech.2016.05.026

PMID:27214511

Abstract

Flavonoids, possessing a basic phenylbenzopyrone core, are important components of the human diet, and are found in many medicinal plants. Flavonoids include chalcones, flavanones and their derivatives. Synthetic and natural isolated flavonoids display an enormous number of biological activities such as antitumor, antiplatelet, anti-malarial, anti-inflammatory, antidepressant and anticonvulsant properties. This review article focuses on the antidepressant-like effect, structure-activity relationship and mechanism of action of total flavonoid extracts isolation from natural sources, flavonoid compounds and their related analogues.

摘要

类黄酮具有基本的苯并吡喃酮核心，是人类饮食的重要组成部分，存在于许多药用植物中。类黄酮包括查耳酮、黄烷酮及其衍生物。合成和天然分离的类黄酮表现出许多生物活性，如抗肿瘤、抗血小板、抗疟疾、抗炎、抗抑郁和抗惊厥特性。本文综述了从天然来源、类黄酮化合物及其相关类似物中分离的总黄酮提取物、黄酮类化合物及其相关类似物的抗抑郁样作用、构效关系和作用机制。