Zhong Jian-Qing, Li Bo, Jia Qi, Li Yi-Ming, Zhu Wei-Liang, Chen Kai-Xian
College of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Yao Xue Xue Bao. 2011 Jun;46(6):622-30.
Flavonoids are a large class of compounds widely distributed in nature. Many pharmacological activities of flavonoids have been reported such as anti-cancer, antioxidant, anti-inflammatory, hepatoprotective, antithrombotic, vasodilator, antiviral, antibacterial, antiallergic, and so on. In recent years, domestic and foreign research groups choose natural flavonoids and optimize their chemical structures in order to develop a number of new derivatives with stronger pharmacological activities. As part of the mechanisms are not clear, we need to strengthen in-depth research in the SAR (structure-activity relationship) study for targeted and efficient structure optimization. This paper systematically summarize current researches in the SAR studies of flavonoids and their derivatives, which can serve as a reference for synthesizing new flavonoid derivatives.
黄酮类化合物是一大类广泛分布于自然界的化合物。黄酮类化合物的许多药理活性已被报道，如抗癌、抗氧化、抗炎、保肝、抗血栓、血管舒张、抗病毒、抗菌、抗过敏等。近年来，国内外研究团队选择天然黄酮类化合物并优化其化学结构，以开发一些具有更强药理活性的新衍生物。由于部分作用机制尚不清楚，我们需要在构效关系（SAR）研究中加强深入研究，以进行有针对性和高效的结构优化。本文系统总结了黄酮类化合物及其衍生物构效关系研究的当前进展，可为合成新的黄酮类衍生物提供参考。
