Regio- and chemoselective synthesis of flavanone isosteres via multicomponent reactions: synergistic role of hydrogen bonding and solvent effects.

Given the prevalence and significance of flavanones, we present a regio- and chemoselective approach for the synthesis of flavanone isosteres. This method is facilitated by the synergistic effects of hydrogen bonding and solvent interactions. Notably, this novel multicomponent reaction employs commercially available starting materials, operates without the need for catalysts, and achieves high levels of regio- and chemoselectivity under mild conditions. The protocol exhibits excellent tolerance for complex substrates, including those derived from Linagliptin and Cholesterol. Furthermore, this robust synthetic method not only surpasses the limitations of traditional approaches but also aligns with the principles of green chemistry.