从津巴布韦的 Monadenium lugardae 中分离和结构鉴定具有抗癌活性的四环三萜。

Isolation and Structure of Cancer Cell Growth Inhibitory Tetracyclic Triterpenoids from the Zimbabwean Monadenium lugardae.

机构信息

Cancer Research Institute and Department of Chemistry and Biochemistry, Arizona State University , PO Box 871604, Tempe, Arizona 85287-1604, United States.

出版信息

J Nat Prod. 2016 Jun 24;79(6):1598-603. doi: 10.1021/acs.jnatprod.6b00107. Epub 2016 May 23.

DOI:10.1021/acs.jnatprod.6b00107

PMID:27214528

Abstract

The Zimbabwean medicinal plant Monadenium lugardae was evaluated as a potential source of new anticancer constituents. Four new tetracyclic triterpene (1-4) were isolated, accompanied by four previously known triterpenes (5-8). Against a panel of human tumor cell lines, lugardstatins 1 (1) and 2 (2) had good cancer cell growth inhibitory activity. All of the triterpene structures (1-8) were established by 1D and 2D NMR spectrometric and HR mass spectrometric analysis.

摘要

津巴布韦药用植物 Monadenium lugardae 被评估为新型抗癌成分的潜在来源。从该植物中分离得到了四个新的四环三萜（1-4），并同时得到了四个先前已知的三萜（5-8）。其中，lugardstatins 1（1）和 2（2）对一组人类肿瘤细胞系具有良好的癌细胞生长抑制活性。通过 1D 和 2D NMR 光谱和高分辨率质谱分析确定了所有三萜的结构（1-8）。