来自阿拉套大戟的两种新三萜类化合物。
Two new triterpenes from Euphorbia alatavica.
作者信息
Rozimamat Rushangul, Kehrimen Nurmuhammat, Gao Jie, Ma Hai-Rong, Aisa Haji Akber
机构信息
a Key Laboratory of Plant Resources and Chemistry of Arid Zone , Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences , Urumqi 830011 , China.
c University of the Chinese Academy of Sciences , Beijing 100039 , China.
出版信息
J Asian Nat Prod Res. 2017 Oct;19(10):966-973. doi: 10.1080/10286020.2017.1307835. Epub 2017 Apr 3.
A phytochemical investigation on Euphorbia alatavica Boiss resulted in the isolation of nine compounds, including two new ones, alatavolide and alatavoic acid (1-2). Chemical structures of these compounds were established on the basis of 1D, 2D NMR, and HR-MS techniques, and by comparison with data reported in the literature. Compounds 1, 2, 4, 6, 8, and 9 were screened for cytotoxicity using the MTT assay. Among these compounds, the new compound 2 showed moderate cytotoxicity against Hela, MCF-7 and A549 cell lines (IC values of 16.4 ± 3.2, 14.5 ± 2.8, 22.3 ± 3.1 μM, respectively), while the known compound 8 exhibited the most potent cytotoxicity with the IC values of 6.5 ± 3.1, 1.9 ± 0.9, 8.6 ± 3.5 μM, respectively.
对阿尔泰山大戟（Euphorbia alatavica Boiss）进行的植物化学研究分离出了9种化合物，其中包括两种新化合物，即阿尔泰山大戟内酯（alatavolide）和阿尔泰山大戟酸（alatavoic acid，1 - 2）。这些化合物的化学结构是基于一维、二维核磁共振（NMR）和高分辨质谱（HR - MS）技术，并与文献报道的数据进行比较而确定的。使用MTT法对化合物1、2、4、6、8和9进行了细胞毒性筛选。在这些化合物中，新化合物2对Hela、MCF - 7和A549细胞系表现出中等细胞毒性（IC值分别为16.4 ± 3.2、14.5 ± 2.8、22.3 ± 3.1 μM），而已知化合物8表现出最强的细胞毒性，IC值分别为6.5 ± 3.1、1.9 ± 0.9、8.6 ± 3.5 μM。
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