Bedrosian Tracy A, Linker Sara, Gage Fred H
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA.
Genome Med. 2016 May 23;8(1):58. doi: 10.1186/s13073-016-0317-9.
The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrotransposon insertions, that are precipitated by modern environmental factors may alter neuronal function and neurological traits, increasing the societal prevalence of mental disorders.
大脑中体细胞镶嵌现象的发现为我们理解基因与环境相互作用在精神疾病风险中的作用提供了新视角。由现代环境因素引发的体细胞突变，如逆转录转座子插入，可能会改变神经元功能和神经特征，从而增加精神障碍在社会中的患病率。
