Han Sang Mi, Pak Sok Cheon, Nicholls Young Mee, Macfarlane Nicola
Department of Agricultural Biology, National Institute of Agricultural Science, Wanju, Korea.
School of Biomedical Sciences, Charles Sturt University, Bathurst, NSW, Australia.
J Cosmet Dermatol. 2016 Dec;15(4):324-329. doi: 10.1111/jocd.12227. Epub 2016 May 24.
Acne vulgaris is a chronic dermatologic disease with four factors involved in the development of lesions. Treatments need to address as many of these underlying factors as possible in order to reduce acne lesions. As such, purified bee venom (PBV ) serum is an attractive therapeutic option for acne, but little data exist on the efficacy of this treatment strategy.
In this prospective, noncomparative study, 30 subjects having mild-to-moderate acne vulgaris were enrolled and treated with PBV serum twice daily for a period of 6 weeks. Clinical evaluation of lesions by expert visual grading and image analysis were made at weeks 0 (baseline), 3, and 6.
The average visual acne grade of all volunteers significantly improved with the PBV serum treatment at weeks 3 (P < 0.05) and 6 (P < 0.001) when compared with the baseline grade at week 0. In addition, there was a mean percent improvement of 8.6% and 52.3% in acne grade observed after 3 and 6 weeks of PBV serum use, with 20% and 77% of the subjects showing improvement, respectively, when compared with baseline. Moreover, the subjects showed improvement in open comedones, closed comedones, papules, pustules, and nodules after 3 and 6 weeks of PBV serum use.
Six weeks of treatment with PBV serum was found to be effective in the treatment of mild-to-moderate acne vulgaris, with no incidence of serious side effects or irritation.
寻常痤疮是一种慢性皮肤病，其皮损形成涉及四个因素。治疗需要尽可能针对这些潜在因素，以减少痤疮皮损。因此，纯化蜂毒（PBV）血清是一种有吸引力的痤疮治疗选择，但关于这种治疗策略的疗效数据很少。
在这项前瞻性、非对照研究中，招募了30名轻至中度寻常痤疮患者，每天两次用PBV血清治疗，为期6周。在第0周（基线）、第3周和第6周通过专家视觉分级和图像分析对皮损进行临床评估。
与第0周的基线分级相比，所有志愿者在第3周（P<0.05）和第6周（P<0.001）使用PBV血清治疗后，平均视觉痤疮分级显著改善。此外，使用PBV血清3周和6周后，痤疮分级平均改善百分比分别为8.6%和52.3%，与基线相比，分别有20%和77%的受试者病情改善。此外，使用PBV血清3周和6周后，受试者的开放性粉刺、闭合性粉刺、丘疹、脓疱和结节均有改善。
发现用PBV血清治疗6周对轻至中度寻常痤疮有效，且无严重副作用或刺激发生。
