International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang 212013, China.
Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, S-106 91 Stockholm, Sweden.
Toxins (Basel). 2020 Jul 11;12(7):451. doi: 10.3390/toxins12070451.
Bee venom (BV) is a rich source of secondary metabolites from honeybees ( L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. The compounds contribute to the venom's observed biological functions as per its anti-inflammatory and anticancer effects. The antimicrobial action of BV has been shown in vitro and in vivo experiments against bacteria, viruses, and fungi. The synergistic therapeutic interactions of BV with antibiotics has been reported. The synergistic effect contributes to a decrease in the loading and maintenance dosage, a decrease in the side effects of chemotherapy, and a decrease in drug resistance. To our knowledge, there have been no reviews on the impact of BV and its antimicrobial constituents thus far. The purpose of this review is to address the antimicrobial properties of BV and its compounds.
蜂毒（BV）是蜜蜂（L.）次生代谢产物的丰富来源。它含有多种生物活性成分，包括肽、蛋白质、酶和挥发性代谢物。这些化合物有助于解释蜂毒的抗炎和抗癌作用等观察到的生物学功能。BV 的抗菌作用已在体外和体内实验中得到证实，可对抗细菌、病毒和真菌。有报道称 BV 与抗生素具有协同治疗作用。这种协同作用有助于降低药物负荷和维持剂量，减少化疗的副作用，并降低耐药性。据我们所知，迄今为止，还没有关于 BV 及其抗菌成分的影响的综述。本综述的目的是探讨 BV 及其化合物的抗菌特性。
