Ambrojo P, Requena Caballero L, Aguilar Martínez A, Sánchez Yus E, Furió V
Department of Dermatology, Hospital Clínico San Carlos, Universidad Complutense de Madrid, Spain.
Dermatologica. 1989;178(3):164-6.
Clear-cell syringoma is a histologic variant of syringoma that is otherwise clinically indistinguishable from ordinary syringoma. This variant is formed by cells that have pale or clear cytoplasm as a result of glycogen accumulation. There is a high association of clear-cell syringoma and diabetes mellitus. A case of clear-cell syringoma associated with diabetes mellitus is described. Electron microscopic examination revealed that periluminal cells showed intra- and extracytoplasmic multivesicular bodies that may be characteristic of the clear-cell variant. Immunohistochemistry for carcinoembryonic antigen (CEA) showed ordinary syringomas as in the presence of CEA within and surrounding duct-like spaces.
透明细胞汗管瘤是汗管瘤的一种组织学变体，在临床上与普通汗管瘤无法区分。这种变体由因糖原积累而具有淡色或透明细胞质的细胞形成。透明细胞汗管瘤与糖尿病高度相关。本文描述了一例与糖尿病相关的透明细胞汗管瘤病例。电子显微镜检查显示，管周细胞显示胞内和胞外多囊泡体，这可能是透明细胞变体的特征。癌胚抗原（CEA）免疫组化显示，普通汗管瘤在导管样间隙内和周围存在CEA。
