Feibelman C E, Maize J C
Am J Dermatopathol. 1984 Apr;6(2):139-50.
The epithelial component of a syringoma is usually composed of cuboidal cells that have a moderate amount of eosinophilic cytoplasm in tissue sections stained with hematoxylin and eosin. Some syringomas have variable numbers of larger epithelial cells that have pale or clear cystoplasm. Such lesions have been called clear-cell syringomas. Examination of 18 cases by conventional microscopy revealed that their general organization is the same as ordinary syringomas but that the epithelial component constitutes a greater proportion of neoplastic volume. Histochemical studies confirmed that the clear cells contain abundant glycogen. The cells near lumina also contained a mucous substance that had a staining profile consistent with sialomucin. Examination by electron microscopy of two lesions composed entirely of clear cells revealed numerous multivesicular bodies, some in large aggregates, in periluminal cells. All cells contained numerous glycogen granules. Lesions in which there were incomplete changes in clear cells tended to have cells predominantly around the lumina. These observations suggest that the majority of clear cells result from accumulation of glycogen. The periluminal cells may be clear owing to the large number of multivesicular bodies and storage of sialomucin in them.
汗腺腺瘤的上皮成分通常由立方体细胞组成，在用苏木精和伊红染色的组织切片中，这些细胞具有中等数量的嗜酸性细胞质。一些汗腺腺瘤有数量不等的较大上皮细胞，其细胞质苍白或透明。这类病变被称为透明细胞汗腺腺瘤。通过传统显微镜检查18例病例发现，它们的总体结构与普通汗腺腺瘤相同，但上皮成分在肿瘤体积中占更大比例。组织化学研究证实，透明细胞含有丰富的糖原。靠近管腔的细胞还含有一种黏液物质，其染色特征与涎黏蛋白一致。对两个完全由透明细胞组成的病变进行电子显微镜检查发现，管腔周围细胞中有大量多囊泡体，有些形成大的聚集体。所有细胞都含有大量糖原颗粒。透明细胞变化不完全的病变往往在管腔周围有较多细胞。这些观察结果表明，大多数透明细胞是糖原积累的结果。管腔周围细胞可能由于大量多囊泡体以及其中涎黏蛋白的储存而呈透明状。
