Asai Y, Ishii M, Hamada T
Acta Derm Venereol. 1982;62(1):64-8.
A case of acral syringoma associated with the usual eruption on the lower eyelids was examined by light and electron microscopy for the first time. In the upper dermis there were a few ducts and cystic formation, while predominant atypical solid strands composed of tumor cells were often seen by light microscopy. Electron microscopy showed the formation of small ducts in the solid strands and numerous microvilli with a pinching off of the luminal tumor cells. A large number of multivesicular dense bodies (mvb) and keratohyalin granules were also found in the periluminal tumor cells. The ducts resembled embryonic intra-epidermal ducts. The unusual anatomical sites of eruption and the electron microscopic findings suggest an eccrine intra-epidermal duct origin of acral syringoma.
首次通过光学显微镜和电子显微镜对1例伴有下眼睑寻常型皮疹的肢端汗管瘤进行了检查。真皮上层有一些导管和囊性结构，而光学显微镜下常可见由肿瘤细胞构成的主要为非典型实性条索。电子显微镜显示实性条索中有小导管形成，且有大量微绒毛，管腔内肿瘤细胞有断头现象。在管腔周围的肿瘤细胞中还发现大量多囊致密小体（mvb）和透明角质颗粒。这些导管类似胚胎期表皮内导管。皮疹不寻常的解剖部位及电子显微镜检查结果提示肢端汗管瘤起源于小汗腺表皮内导管。
