Serra R, Gallelli L, Perri P, De Francesco E M, Rigiracciolo D C, Mastroroberto P, Maggiolini M, de Franciscis S
Interuniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology, University Magna Graecia of Catanzaro, Viale Europa, Catanzaro 88100, Italy; Department of Medical and Surgical Sciences, University of Catanzaro, Catanzaro 88100, Italy.
Department of Health Sciences, University of Catanzaro, Catanzaro 88100, Italy.
Eur J Vasc Endovasc Surg. 2016 Jul;52(1):114-8. doi: 10.1016/j.ejvs.2016.04.020. Epub 2016 May 21.
OBJECTIVE/BACKGROUND: Chronic venous disease (CVD) is a common and relevant problem affecting Western people. The role of estrogens and their receptors in the venous wall seems to support the major prevalence of CVD in women. The effects of the estrogens are mediated by three estrogen receptors (ERs): ERα, ERβ, and G protein-coupled ER (GPER). The expression of ERs in the vessel walls of varicose veins is evaluated.
In this prospective study, patients of both sexes, with CVD and varicose veins undergoing open venous surgery procedures, were enrolled in order to obtain vein samples. To obtain control samples of healthy veins, patients of both sexes without CVD undergoing coronary artery bypass grafting with autologous saphenous vein were recruited (control group). Samples were processed in order to evaluate gene expression.
Forty patients with CVD (10 men [25%], 30 women [75%], mean age 54.3 years [median 52 years, range 33-74 years]) were enrolled. Five patients without CVD (three men, two women [aged 61-73 years]) were enrolled as the control group. A significant increase of tissue expression of ERα, ERβ and GPER in patients with CVD was recorded (p < .01), which was also related to the severity of venous disease.
ERs seem to play a role in CVD; in this study, the expression of ERs correlated with the severity of the disease, and their expression was correlated with the clinical stage.
目的/背景：慢性静脉疾病（CVD）是影响西方人群的常见且相关的问题。雌激素及其受体在静脉壁中的作用似乎支持了女性中CVD的较高患病率。雌激素的作用由三种雌激素受体（ER）介导：ERα、ERβ和G蛋白偶联雌激素受体（GPER）。评估了曲张静脉血管壁中ER的表达。
在这项前瞻性研究中，纳入患有CVD且正在接受开放性静脉手术的静脉曲张患者（无论男女）以获取静脉样本。为了获得健康静脉的对照样本，招募了未患CVD且正在接受自体隐静脉冠状动脉搭桥术的患者（对照组）。对样本进行处理以评估基因表达。
纳入了40例患有CVD的患者（10名男性[25%]，30名女性[75%]，平均年龄54.3岁[中位数52岁，范围33 - 74岁]）。纳入5例未患CVD的患者（3名男性，2名女性[年龄61 - 73岁]）作为对照组。记录到患有CVD的患者中ERα、ERβ和GPER的组织表达显著增加（p <.01），这也与静脉疾病的严重程度相关。
ER似乎在CVD中起作用；在本研究中，ER的表达与疾病严重程度相关，且其表达与临床分期相关。
