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Intramembraneous localization of rat liver microsomal hexose-6-phosphate dehydrogenase and membrane permeability to its substrates.

作者信息

Takahashi T, Hori S H

出版信息

Biochim Biophys Acta. 1978 Jun 9;524(2):262-76. doi: 10.1016/0005-2744(78)90163-8.

DOI:10.1016/0005-2744(78)90163-8
PMID:27221
Abstract

A method for purifying hexose-6-phosphate dehydrogenase (beta-D-glucose: NAD(P) -oxidoreductase, EC 1.1.1.47) from rat liver microsomes is described. The purified enzyme was shown to be homogeneous by sodium dodecyl sulfate (SDS)-polyacrylamide electrophoresis. It is shown that the enzyme is bound to the inner surface of microsomal membranes, and that glucose 6-phosphate, but not NADP, penetrates almost freely into the membranes at 37 degrees C.

摘要

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