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包含甲基1,2,8,8a-四氢环丙基[c]咪唑并[4,5-e]吲哚-4-酮-6-羧酸酯（CImI）烷基化亚基的多卡霉素SA类似物的合成与评价。

Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) alkylation subunit.

作者信息

Chanda Prem B, Boyle Kristopher E, Brody Daniel M, Shukla Vyom, Boger Dale L

机构信息

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Bioorg Med Chem. 2016 Oct 15;24(20):4779-4786. doi: 10.1016/j.bmc.2016.04.050. Epub 2016 Apr 26.

DOI:10.1016/j.bmc.2016.04.050
PMID:27221071
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5052114/
Abstract

The design, synthesis, and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]imidazolo[4,5-e]indol-4-one-6-carboxylate (CImI) derivatives are detailed representing analogs of duocarmycin SA and yatakemycin containing an imidazole replacement for the fused pyrrole found in the DNA alkylation subunit.

摘要

1,2,8,8a-四氢环丙基[c]咪唑并[4,5-e]吲哚-4-酮-6-羧酸甲酯（CImI）衍生物的设计、合成及评估细节如下，这些衍生物是柔红霉素SA和矢车霉素的类似物，在DNA烷基化亚基中含有一个咪唑取代稠合吡咯。

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本文引用的文献

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Tetrahedron. 1991;47(14-15):2661-82.
2
A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents.关于多卡霉素类似物（强效DNA烷基化剂）合成策略的简短综述。
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