Bassal Ravit, Schejter Eduardo, Bachar Rachel, Perri Tamar, Korach Jacob, Jakobson-Setton Ariella, Ben-David Liat Hogen, Cohen Daniel, Keinan-Boker Lital
Department of Epidemiology and Preventive Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Israel E-mail :
Asian Pac J Cancer Prev. 2016;17(4):2067-73. doi: 10.7314/apjcp.2016.17.4.2067.
The aim of the study was to identify risk and protective factors/markers for cervical cancer and cervical intraepithelial neoplasia 3 (CIN3) in Israeli Jewish women in order to settle the discrepancy of low incidence rate of cervical cancer and relatively high incidence rate of CIN3.
We conducted two case control studies, which examined the association between potential risk and protective factors/markers for cervical cancer or CIN3 using self administered detailed questionnaires.
For studying cervical cancer, 40 cases and 40 matched controls were interviewed. In the univariable and multivariable analyses older age, depression or anxiety and ever smoking seemed to act as independent risk factors/markers, while older age at first intercourse was protective. For studying CIN3, 99 cases and 79 controls were interviewed. Multivariable analysis has demonstrated that being born in Israel, depression or anxiety and ever smoking were independent risk factors/markers for CIN3.
The risk factors/markers studied, that were associated with cervical cancer or CIN3 among Jewish women in Israel, are similar to those reported in other parts of the world, and do not explain the observed discrepancy of high in-situ cervical cancer rates and low invasive cervical cancer incidence in Israel.
本研究旨在确定以色列犹太女性宫颈癌和宫颈上皮内瘤变3级（CIN3）的风险及保护因素/标志物，以解决宫颈癌发病率低而CIN3发病率相对较高的差异问题。
我们开展了两项病例对照研究，通过自行填写详细问卷来研究宫颈癌或CIN3的潜在风险及保护因素/标志物之间的关联。
在研究宫颈癌时，对40例病例和40例匹配对照进行了访谈。在单变量和多变量分析中，年龄较大、抑郁或焦虑以及曾经吸烟似乎是独立的风险因素/标志物，而初次性交年龄较大具有保护作用。在研究CIN3时，对99例病例和79例对照进行了访谈。多变量分析表明，在以色列出生、抑郁或焦虑以及曾经吸烟是CIN3的独立风险因素/标志物。
在以色列犹太女性中，所研究的与宫颈癌或CIN3相关的风险因素/标志物与世界其他地区报道的相似，无法解释以色列宫颈癌原位发病率高而浸润性宫颈癌发病率低这一观察到的差异。
