Baskran Krishnan, Kumar P Kranthi, Santha K, Sivakamasundari Inmozhi I
Department of Biochemistry, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalainagar, Tamil Nadu, India.
Department of Genetics, Narayana Medical College & Hospital, Nellore, Andhra Pradesh, India.
Asian Pac J Cancer Prev. 2019 Nov 1;20(11):3415-3419. doi: 10.31557/APJCP.2019.20.11.3415.
Human papilloma viruses (HPVs) are recognized as the major etiological agents of most pre invasive and invasive cancer of the uterine cervix. Many cofactors in association with high-risk HPV (HR-HPV) trigger infection which leads to cervical carcinogenesis. The aim was to study various cofactors and their association with cervical cancer in women infected with HR-HPV.
The present study screened a total of 156 subjects for the presence of HPV infection. Association of various cofactors with cervical cancer was estimated using binary logistic regression analysis.
The HR-HPV infection showed a very significant risk factor for cervical cancer. Among the cofactors, the education level, early sexual exposure and age at pregnancy had no significant association while low socioeconomic status (SES) and high parity showed significant association as risk factors for cervical cancer. Tobacco chewing with betel quid was not significantly associated with cervical cancer.
The present study indicates that low SES is a major risk factor associated with cervical cancer. Bringing awareness about HPV infection and intensifying routine screening programs for cervical cancer will help reduce the risk of cervical cancer among women with low SES in this region.
人乳头瘤病毒（HPV）被认为是大多数子宫颈癌前病变和浸润性癌的主要病因。许多与高危型HPV（HR-HPV）相关的辅助因素会引发感染，进而导致子宫颈癌发生。本研究旨在探讨感染HR-HPV的女性中各种辅助因素及其与子宫颈癌的关联。
本研究共筛查了156名受试者是否感染HPV。采用二元逻辑回归分析评估各种辅助因素与子宫颈癌的关联。
HR-HPV感染是子宫颈癌的一个非常显著的危险因素。在辅助因素中，教育水平、过早性接触和怀孕年龄与子宫颈癌无显著关联，而低社会经济地位（SES）和高生育次数与子宫颈癌呈显著关联，为危险因素。嚼槟榔与子宫颈癌无显著关联。
本研究表明，低SES是与子宫颈癌相关的主要危险因素。提高对HPV感染的认识并加强子宫颈癌的常规筛查计划，将有助于降低该地区低SES女性患子宫颈癌的风险。
