Matrakool Likit, Tongtawee Taweesak, Bartpho Theeraya, Dechsukhum Chavaboon, Loyd Ryan A, Kaewpitoon Soraya J, Kaewpitoon Natthawut
School of Surgery, Institute of Medicine, Suranaree University of Technology, 4Faculty of Public health, Vongchavalitkul University, Nakhon Ratchasima, Thailand E-mail :
Asian Pac J Cancer Prev. 2016;17(4):2099-103. doi: 10.7314/apjcp.2016.17.4.2099.
The gold standard diagnosis of H. pylori related gastritis is evidence of bacteria on histopathological examination of gastric mucosa. Our aim was to study the correlation between gastric mucosal morphology and histopathological severity of H. pylori related gastritis.
Division was made on morphological features into:Type 1, showing regular arrangement of red dots; Type 2, showing cleft-like appearance; Type 3, with a mosaic appearance; and Type 4, having a mosaic appearance with focal or diffuse hyperemia.
Types 1 and 2 gastric mucosal morphologies were statistically significant in predicting an H. pylori negative status (137/145, <0.01), while Types 3 and 4 were significant a positive status (139/155, <0.01). The sensitivity, specificity, positive and negative predictive values of Type 3 and 4 morphologies for predicting H. pylori positive were 94.6%, 89.5%, 89.7% and 94.5%, respectively, with a good correlation with inflammation grading (<0.01).
Our study suggests that gastric mucosal morphology can be reliably identified using conventional white light source gastroscopy with good correlation between findings and inflammation grading.
幽门螺杆菌相关性胃炎的金标准诊断是胃黏膜组织病理学检查发现细菌。我们的目的是研究胃黏膜形态与幽门螺杆菌相关性胃炎组织病理学严重程度之间的相关性。
根据形态学特征分为：1型，表现为红点规则排列；2型，表现为裂隙样外观；3型，呈马赛克样外观；4型，呈马赛克样外观伴局灶性或弥漫性充血。
1型和2型胃黏膜形态在预测幽门螺杆菌阴性状态方面具有统计学意义（145例中有137例，<0.01），而3型和4型在预测阳性状态方面具有统计学意义（155例中有139例，<0.01）。3型和4型形态预测幽门螺杆菌阳性的敏感性、特异性、阳性和阴性预测值分别为94.6%、89.5%、89.7%和94.5%，与炎症分级具有良好的相关性（<0.01）。
我们的研究表明，使用传统白光胃镜可以可靠地识别胃黏膜形态，检查结果与炎症分级之间具有良好的相关性。
