Dore Maria Pina, Pes Giovanni Mario
Dipartimento di Scienze Mediche, Chirurgiche e Sperimentali, University of Sassari, 07100 Sassari, Italy.
Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
J Clin Med. 2021 May 13;10(10):2091. doi: 10.3390/jcm10102091.
infection remains one of the most prevalent infections worldwide, especially in low-resource countries, and the major risk factor for peptic ulcer and gastric cancer. The "test-and-treat" strategy is recommended by several guidelines and consensus. The choice of testing method is based on patient age, presence of alarm signs and/or symptoms, use of non-steroidal anti-inflammatory drugs, as well as local availability, test reliability, and cost. Culture is the gold standard to detect and, possibly, to perform susceptibility testing, however, it requires upper endoscopy and dedicated labs. Recent advances in molecular biology have provided new strategies in detecting infection and antimicrobial resistance without invasive tests. In this review we attempt to offer a comprehensive panorama on the new diagnostic tools and their potential use in clinical settings, in order to accomplish specific recommendations.
幽门螺杆菌感染仍然是全球最普遍的感染之一,尤其是在资源匮乏的国家,并且是消化性溃疡和胃癌的主要危险因素。多项指南和共识推荐采用“检测和治疗”策略。检测方法的选择基于患者年龄、是否存在警示体征和/或症状、非甾体抗炎药的使用情况,以及当地的可及性、检测可靠性和成本。培养是检测幽门螺杆菌以及可能进行药敏试验的金标准,然而,它需要进行上消化道内镜检查并具备专门的实验室。分子生物学的最新进展为无需侵入性检测来检测幽门螺杆菌感染和抗菌药物耐药性提供了新策略。在本综述中,我们试图全面介绍新的诊断工具及其在临床环境中的潜在用途,以便完成具体建议。