Peng Shuping, Gao Dan, Gao Chengde, Wei Pingpin, Niu Man, Shuai Cijun
Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China.
State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, Hunan 410083, P.R. China.
Mol Med Rep. 2016 Jul;14(1):623-9. doi: 10.3892/mmr.2016.5335. Epub 2016 May 24.
Osteogenesis is a complex multi-step process involving the differentiation of mesenchymal stem cells (MSCs) into osteoblast progenitor cells, preosteoblasts, osteoblasts and osteocytes, and the crosstalk between multiple cell types for the formation and remodeling of bone. The signaling regulatory networks during osteogenesis include various components, including growth factors, transcription factors, micro (mi)RNAs and effectors, a number of which form feedback loops controlling the balance of osteogenic differentiation by positive or negative regulation. miRNAs have been found to be important regulators of osteogenic signaling pathways in multiple aspects and multiple signaling pathways. The present review focusses on the progress in elucidating the role of miRNA in the osteogenesis signaling networks of MSCs as a substitute for bone implantation the the field of bone tissue engineering. In particular, the review classifies which miRNAs promote or suppress the osteogenic process, and summarizes which signaling pathway these miRNAs are involved in. Improvements in knowledge of the characteristics of miRNAs in osteogenesis provide an important step for their application in translational investigations of bone tissue engineering and bone disease.
骨生成是一个复杂的多步骤过程，涉及间充质干细胞（MSC）分化为成骨祖细胞、前成骨细胞、成骨细胞和骨细胞，以及多种细胞类型之间的相互作用以形成和重塑骨骼。骨生成过程中的信号调节网络包括各种成分，如生长因子、转录因子、微小（mi）RNA和效应器，其中许多形成反馈环，通过正调控或负调控来控制成骨分化的平衡。已发现miRNA在多个方面和多个信号通路中是成骨信号通路的重要调节因子。本综述聚焦于阐明miRNA在MSC骨生成信号网络中的作用方面的进展，作为骨组织工程领域骨植入替代物。特别是，该综述对促进或抑制成骨过程的miRNA进行了分类，并总结了这些miRNA参与哪些信号通路。对miRNA在骨生成中特性的认识的提高为其在骨组织工程和骨疾病转化研究中的应用迈出了重要一步。
