Huang Cong, Geng Junnan, Jiang Siwen
Key Laboratory of Swine Genetics and Breeding of Agricultural Ministry, College of Animal Science and Technology, Huazhong Agricultural University, No.1 Shizishan Street, Wuhan, Hubei, 430070, China.
The Cooperative Innovation Center for Sustainable Pig Production, Wuhan, China.
Cell Tissue Res. 2017 May;368(2):229-238. doi: 10.1007/s00441-016-2462-2. Epub 2016 Jul 18.
Mesenchymal stem cells (MSCs), also referred to as multipotent stromal cells, have been isolated from various adult tissue sources because of their capabilities of differentiating into multiple cell lineages including osteoblasts, thus providing a novel approach for treating bone diseases and metabolic disorders. Despite extensive potential in cell therapy and widespread interest in clinical applications of MSCs, the molecular mechanisms with regard to the regulation of their therapeutic properties and osteoblast differentiation remain to be fully elucidated. MicroRNAs (miRNAs), a novel class of endogenous small noncoding RNAs, regulate gene expressions by translational repression or degradation of their targets. Recently, emerging evidence has shown that miRNAs are closely involved in controlling the key steps of osteoblast differentiation in MSCs. This review focuses on miRNAs and their roles in regulating osteogenic differentiation of MSCs.
间充质干细胞（MSCs），也被称为多能基质细胞，因其能够分化为包括成骨细胞在内的多种细胞谱系，已从各种成人组织来源中分离出来，从而为治疗骨疾病和代谢紊乱提供了一种新方法。尽管MSCs在细胞治疗方面具有广泛潜力且在临床应用中受到广泛关注，但其治疗特性调节和成骨细胞分化的分子机制仍有待充分阐明。微小RNA（miRNAs）是一类新型的内源性小非编码RNA，通过抑制翻译或降解其靶标来调节基因表达。最近，新出现的证据表明，miRNAs密切参与控制MSCs中成骨细胞分化的关键步骤。本综述聚焦于miRNAs及其在调节MSCs成骨分化中的作用。
