Liu Juan, Jung Jee H, Liu Yonghong
Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Curr Med Chem. 2016;23(25):2892-2905. doi: 10.2174/0929867323666160525113837.
It is known that marine invertebrates, including sponges, tunicates, cnidaria or mollusks, host affluent and various communities of symbiotic microorganisms. The microorganisms associated with the invertebrates metabolized various biologically active compounds, which could be an important resource for the discovery and development of potentially novel drugs. In this review, the new compounds with antimicrobial activity isolated from marine invertebrate-derived microorganisms in the last decade (2004-2014) will be presented, with focus on the relevant antimicrobial activities, origin of isolation, and information of strain species. New compounds without antimicrobial activity were not revealed.
众所周知,包括海绵动物、被囊动物、刺胞动物或软体动物在内的海洋无脊椎动物拥有丰富多样的共生微生物群落。与这些无脊椎动物相关的微生物能代谢多种生物活性化合物,这可能是发现和开发潜在新型药物的重要资源。在本综述中,将介绍过去十年(2004 - 2014年)从海洋无脊椎动物源微生物中分离出的具有抗菌活性的新化合物,重点关注相关抗菌活性、分离来源及菌株种类信息。未发现无抗菌活性的新化合物。