Sable Rushikesh, Parajuli Pravin, Jois Seetharama
Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe, 1800 Bienville Drive, Monroe, LA 71201, USA.
Mar Drugs. 2017 Apr 22;15(4):124. doi: 10.3390/md15040124.
Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market.
自然界提供了多种在大多数生物物种中表达的肽。进化压力和自然选择创造并优化了这些肽，使其能够与受体高亲和力结合。因此，自然资源为基于肽的药物研发提供了丰富的化学空间以供探索。海洋肽可以通过简单的溶剂萃取技术提取。分析技术的进步使得从自然资源中获得纯肽成为可能。已对提取的肽作为多种疾病的潜在治疗剂进行了评估，包括抗菌、抗真菌、抗糖尿病和抗癌活性以及心血管和神经毒素活性。尽管海洋资源提供了数千种可能的肽，但只有少数源自海洋的肽进入了医药市场。本综述聚焦于过去十年中一些源自海洋的肽，并简要介绍了那些目前正在进行临床试验或已上市的肽。
