Park Byung Kwan, Park Ji Won, Han Eon Chul, Ryoo Seung-Bum, Han Sae-Won, Kim Tae-You, Chie Eui Kyu, Jeong Seung-Yong, Park Kyu Joo
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Cancer Research Institute, Seoul National University, Seoul, Korea.
J Surg Oncol. 2016 Aug;114(2):216-21. doi: 10.1002/jso.24299. Epub 2016 May 24.
The aim of this study was to evaluate systemic inflammatory markers as prognostic factors in patients with stage IIA colorectal cancer.
Among the patients who underwent curative resection for colorectal cancer at Seoul National University Hospital between 2002 and 2010, 1,035 who were classified as postoperative pathologic stage IIA (T3N0M0) were included. Systemic inflammatory markers, such as the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet-to-lymphocyte ratio (PLR), prognostic nutritional index (PNI), and serum fibrinogen level, were retrospectively reviewed. The patients were divided into two groups according to the cut-off values of the systemic inflammatory markers after receiver operating characteristic (ROC) curve analysis. Survival analysis was performed to identify factors associated with disease-free survival (DFS) and overall survival (OS).
Age, American Society of Anesthesiologists (ASA) score, tumor location, number of harvested lymph nodes, venous invasion, perineural invasion, adjuvant treatment and PNI (HR = 1.534, 95%CI: 1.065-2.211, P = 0.022; HR = 1.915, 95%CI: 1.286-2.852, P = 0.001 for DFS and OS, respectively) were independent significant prognostic factors for both DFS and OS.
PNI can be a prognostic marker in stage IIA colorectal cancer. J. Surg. Oncol. 2016;114:216-221. © 2016 Wiley Periodicals, Inc.
本研究旨在评估全身炎症标志物作为IIA期结直肠癌患者的预后因素。
在2002年至2010年间于首尔国立大学医院接受结直肠癌根治性切除术的患者中，纳入1035例术后病理分期为IIA期（T3N0M0）的患者。回顾性分析全身炎症标志物，如中性粒细胞与淋巴细胞比值（NLR）、衍生中性粒细胞与淋巴细胞比值（dNLR）、血小板与淋巴细胞比值（PLR）、预后营养指数（PNI）和血清纤维蛋白原水平。在接受者操作特征（ROC）曲线分析后，根据全身炎症标志物的临界值将患者分为两组。进行生存分析以确定与无病生存（DFS）和总生存（OS）相关的因素。
年龄、美国麻醉医师协会（ASA）评分、肿瘤位置、收获的淋巴结数量、静脉侵犯、神经周围侵犯、辅助治疗和PNI（HR = 1.534，95%CI：1.065 - 2.211，P = 0.022；DFS和OS的HR分别为1.915，95%CI：1.286 - 2.852，P = 0.001）是DFS和OS的独立显著预后因素。
PNI可作为IIA期结直肠癌的预后标志物。《外科肿瘤学杂志》2016年；114：216 - 221。©2016威利期刊公司。
