Yang Jing, Guo Xinli, Wu Tong, Niu Kaifan, Ma Xuelei
State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy.
West China School of Medicine, West China Hospital, Sichuan University, Chengdu, China.
Medicine (Baltimore). 2019 Feb;98(6):e14420. doi: 10.1097/MD.0000000000014420.
Inflammation-based indexes such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), and systemic immune-inflammation indexes (SII) have been reported to be associated with prognosis in cancer patients.The aim of this study was to estimate the prognostic significance of inflammation-based indexes such as NLR, PLR, LMR, and SII in stage III/IV colorectal cancer (CRC) patients undertaking adjuvant chemoradiotherapy (CRT).Two hundred twenty stage III/IV CRC patients were enrolled in this study. Inflammatory indexes were defined as follows: NLR = absolute neutrophil counts/absolute lymphocyte counts; PLR = absolute platelet counts/absolute lymphocyte counts; LMR = absolute lymphocyte counts/absolute monocyte counts; SII = absolute neutrophil counts × absolute platelet counts/absolute lymphocyte counts. The correlations between indexes and prognosis were evaluated using the Cox proportional hazard model.The results of univariate analysis demonstrated that NLR, PLR, and SII were significantly associated with progression-free survival (PFS) and overall survival (OS). Multivariate analysis showed that SII (P = .030) was an independent predictor of PFS, and NLR (P = .047) was an independent prognostic factor of OS.Those inflammation-based indexes could provide a convenient and secure method to predict the outcomes of stage III/IV CRC patients receiving adjuvant CRT.
据报道，基于炎症的指标，如中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）、淋巴细胞与单核细胞比值（LMR）以及全身免疫炎症指标（SII），与癌症患者的预后相关。本研究的目的是评估NLR、PLR、LMR和SII等基于炎症的指标在接受辅助放化疗（CRT）的III/IV期结直肠癌（CRC）患者中的预后意义。本研究纳入了220例III/IV期CRC患者。炎症指标定义如下：NLR = 中性粒细胞绝对值/淋巴细胞绝对值；PLR = 血小板绝对值/淋巴细胞绝对值；LMR = 淋巴细胞绝对值/单核细胞绝对值；SII = 中性粒细胞绝对值×血小板绝对值/淋巴细胞绝对值。使用Cox比例风险模型评估指标与预后之间的相关性。单因素分析结果表明，NLR、PLR和SII与无进展生存期（PFS）和总生存期（OS）显著相关。多因素分析显示，SII（P = 0.030）是PFS的独立预测因素，NLR（P = 0.047）是OS的独立预后因素。这些基于炎症的指标可为预测接受辅助CRT的III/IV期CRC患者的预后提供一种方便且可靠的方法。
