Gheibi Sh, Noroozi M, Hejazi S, Karamyyar M, Farrokh-Eslamlou H
Iran J Ped Hematol Oncol. 2016;6(1):64-9. Epub 2016 Mar 15.
Iron-deficiency anemia is a widespread public health problem with major consequences for human health especially, children. However, in a fraction of patients an underlying cause is never found during routine investigation. Recent studies have suggested an association between Helicobacter pylori (H. Pylori) infection and iron-deficiency anemia.
Here is reported four school aged children (two male, two female) with refractory severe iron-deficiency anemia associated H. Pylori gastritis. Mean age of the patients was 13.62 years old and they were admitted with chief complaints of abdominal, chest pain weakness, headache and respiratory distress. Mean hemoglobin level in patients was 6.2 g/dl with persistence to iron therapy. After the diagnosis and therapy of H. pylori infection, clinical complaints, hemoglobin level and iron profiles were being normal and they gained weight.
This study suggests screening of H. pylori infection and appropriate treatment in any case of refractory moderate to severe iron-deficiency anemia, especially with clinical manifestations of gastrointestinal tract in children.
缺铁性贫血是一个广泛存在的公共卫生问题，对人类健康尤其是儿童健康有重大影响。然而，在一部分患者中，常规检查始终未能找到潜在病因。最近的研究表明幽门螺杆菌（H. Pylori）感染与缺铁性贫血之间存在关联。
本文报道了4名学龄儿童（2名男性，2名女性），他们患有难治性重度缺铁性贫血并伴有幽门螺杆菌胃炎。患者的平均年龄为13.62岁，入院时的主要症状为腹痛、胸痛、虚弱、头痛和呼吸窘迫。患者的平均血红蛋白水平为6.2 g/dl，铁剂治疗后仍持续存在。在诊断和治疗幽门螺杆菌感染后，临床症状、血红蛋白水平和铁代谢指标均恢复正常，且体重增加。
本研究表明，对于任何难治性中度至重度缺铁性贫血病例，尤其是伴有胃肠道临床表现的儿童，应筛查幽门螺杆菌感染并进行适当治疗。
